Influenza A virions possess two surface glycoproteins—the hemagglutinin (HA) and
neuraminidase (NA)—which exert opposite functions. HA attaches virions to cells by binding …

Neuraminidase promotes influenza virus release from infected cells and facilitates virus
spread within the respiratory tract. Several potent and specific inhibitors of this enzyme have …

This report updates the 2004 recommendations by the Advisory Committee on Immunization
Practices (ACIP) regarding the use of influenza vaccine and antiviral agents (CDC …

This report updates the 2008 recommendations by CDC's Advisory Committee on
Immunization Practices (ACIP) regarding the use of influenza vaccine for the prevention and …

The gene pool of influenza A viruses in aquatic birds provides all of the genetic diversity
required for human and lower animals. Host range selection of the receptor binding …

Oseltamivir is a prodrug of oseltamivir carboxylate (Ro 64-0802, GS4071), a potent and
selective inhibitor of the neuraminidase glycoprotein essential for replication of influenza A …

Zanamivir, a neuraminidase inhibitor, has shown promise as a drug to control influenza.
During prolonged treatment with zanamivir, a mutant virus was isolated from an …

The influenza virus neuraminidase (NA) inhibitors zanamivir and oseltamivir were
introduced into clinical practice in various parts of the world between 1999 and 2002. In …

This report updates the 2006 recommendations by CDC's Advisory Committee on
Immunization Practices (ACIP) regarding the use of influenza vaccine and antiviral agents …

Influenza virus is a negative stranded RNA virus. It contains two surface glycoproteins,
hemagglutinin (HA) and neuraminidase (NA). HA exists as a trimer and is responsible for …