Increased body weight and metabolic disorder including insulin resistance, type 2 diabetes
and cardiovascular complications together constitute metabolic syndrome. The …

Hypertension is a major risk factor for myocardial infarction, heart failure, stroke, peripheral
arterial disease, and aortic aneurysm, and is a cause of chronic kidney disease …

Chronic inflammatory state in obesity causes dysregulation of the endocrine and paracrine
actions of adipocyte-derived factors, which disrupt vascular homeostasis and contribute to …

Reactive oxygen species (ROS) are important molecules in the living organisms as a part of
many signaling pathways. However, if overproduced, they also play a significant role in the …

Hypertension is considered to be the most important risk factor in the development of
cardiovascular disease. An increasing body of evidence suggests that oxidative stress …

Obesity is a risk factor for developing type 2 diabetes and cardiovascular disease and has
quickly become a worldwide pandemic with few tangible and safe treatment options …

Essential hypertension is a highly prevalent pathological condition that is considered as one
of the most relevant cardiovascular risk factors and is an important cause of morbidity and …

Diabetes Mellitus (DM), a state of chronic hyperglycemia, is a major cause of serious micro
and macrovascular diseases, affecting, therefore, nearly every system in the body. Growing …

Inflammation is a condition that underscores many cardiovascular pathologies including
endothelial dysfunction, but no link is yet established between the vascular pathology of the …

Vascular nitric oxide (NO•) resistance, manifested by an impaired vasodilator function of NO•
in both the macro-and microvessels, is a common state in type 2 diabetes (T2D) associated …