• The specific situation of the patient. Unless otherwise provided for by national regulations,
off-label use of medication should be limited to situations where it is in the patient's interest …

Abstract Establishment of the Heart Team concept in the field of cardiovascular medicine
has resulted in quality improvement in the management of heart valve disease and heart …

Importance Practice guidelines often provide recommendations in which the strength of the
recommendation is dissociated from the quality of the evidence. Objective To create a …

Infective endocarditis (IE) is a rare but potentially life-threatening disease, sometimes with
longstanding sequels among surviving patients. The population at high risk of IE is …

• The specific situation of the patient. Unless otherwise provided for by national regulations,
off-label use of medication should be limited to situations where it is in the patient's interest …

Background Persons who inject drugs (PWID) are at risk of invasive infections; however,
hospitalizations to treat these infections are frequently complicated by against medical …

Background The management of infective endocarditis (IE) is complex owing to a high
burden of morbidity and mortality. Recent guidelines recommend dedicated multidisciplinary …

Background Infectious endocarditis is associated with substantial in-hospital mortality of
15%-20%. Effective management requires coordination between multiple medical and …

Infective endocarditis (IE) remains a difficult condition to diagnose and treat and is an
infection of high consequence for patients, causing long hospital stays, life-changing …

Objectives Drug use–associated infective endocarditis is a rapidly growing clinical problem.
Although operative outcomes are generally satisfactory, reinfection secondary to recurrent …