The biophysical modeling efforts in diffusion MRI have grown considerably over the past 25
years. In this review, we dwell on the various challenges along the journey of bringing a …

Microstructure imaging seeks to noninvasively measure and map microscopic tissue
features by pairing mathematical modeling with tailored MRI protocols. This article reviews …

Biophysical models of diffusion in white matter have been center-stage over the past two
decades and are essentially based on what is now commonly referred to as the “Standard …

NMR spectroscopy has been applied to cells and tissues analysis since its beginnings, as
early as 1950. We have attempted to gather here in a didactic fashion the broad diversity of …

Characterizing neural tissue microstructure is a critical goal for future neuroimaging.
Diffusion MRI (dMRI) provides contrasts that reflect diffusing spins' interactions with myriad …

The dependence of the diffusion MRI signal on the diffusion time t is a hallmark of tissue
microstructure at the scale of the diffusion length. Here we measure the time-dependence of …

Intranasal administration is a drug delivery approach to provide a non-invasive
pharmacological response in the central nervous system with relatively small peripheral side …

Abstract Diffusion Magnetic Resonance Imaging (dMRI) is one of the most important
contemporary non-invasive modalities for probing tissue structure at the microscopic scale …

Transmembrane water exchange, including intra-to-extravascular and intra-to-extracellular
ones, are potential biomarkers in the diagnosis and understanding of cancers, brain …

For its size, the brain is the most metabolically active organ in the body. Most of its energy
demand is used to maintain stable homeostatic physiological conditions. Altered …