It is now widely appreciated that members of the matrix metalloproteinase (MMP) family of
enzymes play a key role in cancer development and progression along with many of the …

ADAM proteases are multi domain transmembrane metalloproteases that cleave a range of
cell surface proteins and activate signaling pathways implicated in tumor progression …

The capacity to survive and thrive in conditions of limited resources and high inflammation is
a major driver of tumor malignancy. Here we identified slow-cycling ADAM12+ PDGFRα+ …

Different tumor microenvironments (TMEs) induce stromal cell plasticity that affects
tumorigenesis. The impact of TME-dependent heterogeneity of tumor endothelial cells …

Objective This study is designed to identify genes and pathways that could promote
metastasis to the bowel in high-grade serous ovarian cancer (OC) and evaluate their …

Patient‐derived samples present an advantage over current cell line models of high‐grade
serous ovarian cancer (HGSOC) that are not always reliable and phenotypically faithful …

Background A disintegrin and metalloprotease 12 (ADAM12) is a member of the
multidomain protein family, but the mechanisms by which it affects prognosis and immune …

Abstract ADAM12,(AD isintegrin a nd m etalloproteinase domain-containing protein 12), is
upregulated in epithelial cancers and contributes to increased tumor proliferation …

Ovarian cancer is a serious threat to women's health; its early diagnosis rate is low and
prone to metastasis and recurrence. The current conventional treatment for ovarian cancer is …

The purinergic system is fundamental in the tumor microenvironment, since it regulates
tumor cell interactions with the immune system, as well as growth and differentiation in …