Loss of functional β-cell mass is the key mechanism leading to the two main forms of
diabetes mellitus—type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) …

Enhancers are genomic sequences that play a key role in regulating tissue-specific gene
expression levels. An increasing number of diseases are linked to impaired enhancer …

We assembled an ancestrally diverse collection of genome-wide association studies
(GWAS) of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls …

Insulin resistance is one of the earliest defects in the pathogenesis of type 2 diabetes. Over
the past 50 years, elucidation of the insulin signalling network has provided important …

Genome-wide association studies (GWAS) have provided insights into the genetic basis of
complex diseases. In the next step, integrative multi-omics approaches can characterize …

The spatiotemporal control of gene expression is dependent on the activity of cis-acting
regulatory sequences, called enhancers, which regulate target genes over variable genomic …

Summary Three-dimensional (3D) chromatin organization maps help dissect cell-type-
specific gene regulatory programs. Furthermore, 3D chromatin maps contribute to …

Type 2 diabetes (T2D) is associated with defective insulin secretion and reduced β cell
mass. Available treatments provide a temporary reprieve, but secondary failure rates are …

Three-dimensional organization of the genome is important for transcriptional regulation,,,,,–
. In mammals, CTCF and the cohesin complex create submegabase structures with elevated …

Epigenetics has enriched human disease studies by adding new interpretations to disease
features that cannot be explained by genetic and environmental factors. However …