Randomized Controlled Trials of Rehabilitation in Multiple Sclerosis: Barriers and Unmet Needs

RW Motl - Multiple Sclerosis Journal, 2024 - journals.sagepub.com
Randomized controlled trials (RCTs) provide the foundation of evidence-based practice for
the application of rehabilitation as complementary of medications for filling in the gaps and …

Advancements and Challenges in Exercise Training for Multiple Sclerosis: Comprehensive Review and Future Directions for Randomized Controlled Trials

RW Motl, LA Pilutti - Neurology and Therapy, 2024 - Springer
Exercise training represents a health behavior for the treatment and management of the
multi-faceted manifestations of multiple sclerosis (MS). This paper provides a …

Rationale and methodology for examining the combination of aerobic exercise and cognitive rehabilitation on new learning and memory in persons with multiple …

CLA Wender, O Arbelaez, TT Tong, A Salter… - Contemporary Clinical …, 2024 - Elsevier
Background This paper describes the protocol for a Phase I/II, parallel-group, single-blind
randomized controlled trial (RCT). The RCT investigates the combined effects of 12-weeks …

Remotely-delivered exercise training program for improving physical and cognitive functions among older adults with multiple sclerosis: Protocol for an NIH stage-I …

P Zheng, SA Phillips, J Duffecy, SR DeJonge… - Contemporary Clinical …, 2024 - Elsevier
Background Older adults with multiple sclerosis (MS) present with low physical activity
participation, cognitive and ambulatory dysfunctions, and compromised quality of life (QOL) …

Study protocol: exercise training for treating major depressive disorder in multiple sclerosis

RW Motl, CH Bombardier, J Duffecy, B Hibner… - BMC neurology, 2024 - Springer
Background Major depressive disorder (MDD) is prevalent, yet sub-optimally treated among
persons with multiple sclerosis (MS). We propose that exercise training may be a promising …

Heterogeneity of aerobic fitness changes with exercise training in progressive multiple sclerosis: Secondary, exploratory analysis of data from the CogEx trial

RW Motl, BM Sandroff, RS Hernandez… - Multiple Sclerosis …, 2024 - journals.sagepub.com
Background There is heterogeneity of aerobic fitness (VO2peak) changes with a
standardized exercise training stimulus in the general population (ie some participants …