ATP-dependent chromatin remodeling: genetics, genomics and mechanisms
DC Hargreaves, GR Crabtree - Cell research, 2011 - nature.com
Macromolecular assemblies that regulate chromatin structure using the energy of ATP
hydrolysis have critical roles in development, cancer, and stem cell biology. The ATPases of …
hydrolysis have critical roles in development, cancer, and stem cell biology. The ATPases of …
The biology of chromatin remodeling complexes
CR Clapier, BR Cairns - Annual review of biochemistry, 2009 - annualreviews.org
The packaging of chromosomal DNA by nucleosomes condenses and organizes the
genome, but occludes many regulatory DNA elements. However, this constraint also allows …
genome, but occludes many regulatory DNA elements. However, this constraint also allows …
Enhancer–promoter contact formation requires RNAPII and antagonizes loop extrusion
Homotypic chromatin interactions and loop extrusion are thought to be the two main drivers
of mammalian chromosome folding. Here we tested the role of RNA polymerase II (RNAPII) …
of mammalian chromosome folding. Here we tested the role of RNA polymerase II (RNAPII) …
Mammalian ISWI and SWI/SNF selectively mediate binding of distinct transcription factors
Chromatin remodelling complexes evict, slide, insert or replace nucleosomes, which
represent an intrinsic barrier for access to DNA. These remodellers function in most aspects …
represent an intrinsic barrier for access to DNA. These remodellers function in most aspects …
Control of inducible gene expression links cohesin to hematopoietic progenitor self-renewal and differentiation
Cohesin is important for 3D genome organization. Nevertheless, even the complete removal
of cohesin has surprisingly little impact on steady-state gene transcription and enhancer …
of cohesin has surprisingly little impact on steady-state gene transcription and enhancer …
Controlling the double helix
G Felsenfeld, M Groudine - Nature, 2003 - nature.com
Chromatin is the complex of DNA and proteins in which the genetic material is packaged
inside the cells of organisms with nuclei. Chromatin structure is dynamic and exerts …
inside the cells of organisms with nuclei. Chromatin structure is dynamic and exerts …
[HTML][HTML] Cohesins functionally associate with CTCF on mammalian chromosome arms
V Parelho, S Hadjur, M Spivakov, M Leleu, S Sauer… - Cell, 2008 - cell.com
Cohesins mediate sister chromatid cohesion, which is essential for chromosome
segregation and postreplicative DNA repair. In addition, cohesins appear to regulate gene …
segregation and postreplicative DNA repair. In addition, cohesins appear to regulate gene …
Retrotransposons regulate host genes in mouse oocytes and preimplantation embryos
A comprehensive analysis of transposable element (TE) expression in mammalian full-
grown oocytes reveals that LTR class III retrotransposons make an unexpectedly high …
grown oocytes reveals that LTR class III retrotransposons make an unexpectedly high …
The cohesin complex and its roles in chromosome biology
JM Peters, A Tedeschi, J Schmitz - Genes & development, 2008 - genesdev.cshlp.org
Cohesin is a chromosome-associated multisubunit protein complex that is highly conserved
in eukaryotes and has close homologs in bacteria. Cohesin mediates cohesion between …
in eukaryotes and has close homologs in bacteria. Cohesin mediates cohesion between …
Symmetric dimethylation of H3R2 is a newly identified histone mark that supports euchromatin maintenance
The asymmetric dimethylation of histone H3 arginine 2 (H3R2me2a) acts as a repressive
mark that antagonizes trimethylation of H3 lysine 4. Here we report that H3R2 is also …
mark that antagonizes trimethylation of H3 lysine 4. Here we report that H3R2 is also …