Inflammasomes are critical sentinels of the innate immune system that respond to threats to
the host through recognition of distinct molecules, known as pathogen-or damage …

Currently, pyroptosis has received more and more attention because of its association with
innate immunity and disease. The research scope of pyroptosis has expanded with the …

Pyroptosis is the process of inflammatory cell death. The primary function of pyroptosis is to
induce strong inflammatory responses that defend the host against microbe infection …

The mammalian NLR gene family was first reported over 20 years ago, although several
genes that were later grouped into the family were already known at that time. Although it is …

Sepsis is defined as life-threatening organ dysfunction caused by dysregulated host
systemic inflammatory and immune response to infection. Over decades, advanced …

Pyroptosis refers to the process of gasdermin-mediated lytic programmed cell death (PCD)
characterized by the release of pro-inflammatory cytokines. Our knowledge of pyroptosis has …

Caspases are a family of conserved cysteine proteases that play key roles in programmed
cell death and inflammation. In multicellular organisms, caspases are activated via …

The NLRP3 inflammasome is a critical component of the innate immune system that
mediates caspase-1 activation and the secretion of proinflammatory cytokines IL-1β/IL-18 in …

The study of innate immunity and its link to inflammation and host defense encompasses
diverse areas of biology, ranging from genetics and biophysics to signal transduction and …

In response to a wide range of stimulations, host cells activate pyroptosis, a kind of
inflammatory cell death which is provoked by the cytosolic sensing of danger signals and …