The hypocretins (Hcrts), also known as orexins, are two neuropeptides produced exclusively
in the lateral hypothalamus. They act on two specific receptors that are widely distributed …

This paper reviews evidence demonstrating a bidirectional relationship between memory
and eating in humans and rodents. In humans, amnesia is associated with impaired …

Sleep loss disrupts consolidation of hippocampus-dependent memory. To characterize
effects of learning and sleep loss, we quantified activity-dependent phosphorylation of …

In the brain, long-term memories correspond to changes in synaptic weights after certain
patterns of neural activity. Behaviourally, this corresponds to a change in action evoked by a …

Midlife obesity is a risk factor for cognitive decline and is associated with the earlier onset of
Alzheimer's disease (AD). Diets high in saturated fat potentiate the onset of obesity …

Orexin (also known as hypocretin) neurons in the hypothalamus play an essential role in
sleep–wake control, feeding, reward, and energy homeostasis. The likelihood of anesthesia …

Orexins [orexin-A (OXA) and orexin-B (OXB)] are two isoforms of neuropeptides produced by
the hypothalamus. The main biological actions of orexins, focused on the central nervous …

Cognitive impairment (CI) related to Alzheimer's disease (AD) and vascular cognitive
disorders (VCDs) has become a key problem worldwide. Importantly, CI is a …

In this review study, we aimed to introduce the orexinergic system as an important signaling
pathway involved in a variety of cognitive functions such as memory, motivation, and reward …

Parkinson's disease (PD) is a common neurodegenerative disorder characterized by
progressive and selective death of dopaminergic neurons. Orexin-A is involved in many …