Histone deacetylases inhibitors in neurodegenerative diseases, neuroprotection and neuronal differentiation

S Shukla, BL Tekwani - Frontiers in pharmacology, 2020 - frontiersin.org
Histone deacetylases (HADC) are the enzymes that remove acetyl group from lysine residue
of histones and non-histone proteins and regulate the process of transcription by binding to …

Protein misfolding and ER stress in Huntington's disease

T Shacham, N Sharma… - Frontiers in molecular …, 2019 - frontiersin.org
Increasing evidence in recent years indicates that protein misfolding and aggregation,
leading to ER stress, are central factors of pathogenicity in neurodegenerative diseases …

Mitochondria in Huntington's disease: implications in pathogenesis and mitochondrial-targeted therapeutic strategies

A Jurcau, CM Jurcau - Neural Regeneration Research, 2023 - journals.lww.com
Huntington's disease is a genetic disease caused by expanded CAG repeats on exon 1 of
the huntingtin gene located on chromosome 4. Compelling evidence implicates impaired …

Mitochondrial dysfunction in repeat expansion diseases

A Giménez-Bejarano, E Alegre-Cortés… - Antioxidants, 2023 - mdpi.com
Repeat expansion diseases are a group of neuromuscular and neurodegenerative
disorders characterized by expansions of several successive repeated DNA sequences …

Dopamine in the regulation of glucose homeostasis, pathogenesis of type 2 diabetes, and chronic conditions of impaired dopamine activity/metabolism: Implication for …

G Lisco, A De Tullio, M Iovino, O Disoteo… - Biomedicines, 2023 - mdpi.com
Dopamine regulates several functions, such as voluntary movements, spatial memory,
motivation, sleep, arousal, feeding, immune function, maternal behaviors, and lactation …

Spermatozoan metabolism as a non-traditional model for the study of Huntington's disease

M Lawlor, M Zigo, K Kerns, IK Cho… - International Journal of …, 2022 - mdpi.com
Huntington's Disease (HD) is a fatal autosomal dominant neurodegenerative disease
manifested through motor dysfunction and cognitive deficits. Decreased fertility is also …

Mild cognitive impairment in Huntington's disease: challenges and outlooks

KA Jellinger - Journal of Neural Transmission, 2024 - Springer
Although Huntington's disease (HD) has classically been viewed as an autosomal-dominant
inherited neurodegenerative motor disorder, cognitive and/or behavioral changes are …

Latent Toxoplasma gondii infection increases soluble mutant huntingtin and promotes neurodegeneration in the YAC128 mouse model of Huntington's disease

DW Donley, T Jenkins, C Deiter, R Campbell… - bioRxiv, 2019 - biorxiv.org
Toxoplasma gondii causes a prevalent neuroinvasive protozoal pathogen that in immune
competent individuals results in latent infection characterized by intra-cellular parasite cysts …

[PDF][PDF] Increased chromosome instability and correlated cell death in frontotemporal lobar degeneration

J Caneus - 2018 - … .digitalcollections.cuanschutz.edu
Certain abnormal conditions that affect the nervous system—collectively known as
neurodegenerative diseases—are associated with cognitive impairment due to neuronal …

Applying Encoding and Retrieval Techniques to Chinese Rhyme Reading in Advanced Placement Chinese Instruction

N Wang - 2017 - digitalcommons.unl.edu
Learning Chinese as a foreign language is increasingly prevalent in public school districts in
the US As ACTFL (2011) reported, an increasing number of enrollments of Advanced …