Tropomyosin receptor kinase B (TrkB) and its primary ligand brain-derived neurotrophic
factor (BDNF) are expressed in the neuromuscular system, where they affect neuronal …

Axons are processes of neurons, up to a metre long, that form the essential biological cables
wiring nervous systems. They must survive, often far away from their cell bodies and up to a …

Motoneurons critically depend on precise spatial and temporal control of translation for axon
growth and the establishment and maintenance of neuromuscular connections. While …

Gain-of-function mutations in the housekeeping gene GARS1, which lead to the expression
of toxic versions of glycyl-tRNA synthetase (GlyRS), cause the selective motor and sensory …

Transactivation of Tropomyosin receptor kinase B (TrkB) by EGF leads to cell surface
transport of TrkB, promoting its signaling responsiveness to brain-derived neurotrophic …

Synaptic elements from neuromuscular junctions (NMJs) undergo massive morphological
and functional changes upon nerve injury. While morphological changes of NMJ‐associated …

Amyotrophic lateral sclerosis is a progressive neurodegenerative disease that affects motor
neurons in the spinal cord, brainstem and motor cortex, leading to paralysis and eventually …

Plastin 3 (PLS3) is an F-actin-bundling protein that has gained attention as a modifier of
spinal muscular atrophy (SMA) pathology. SMA is a lethal pediatric neuromuscular disease …

Axons are the narrow, up-to-meter long cellular processes of neurons that form the
biological cables wiring our nervous system. Most axons must survive for an organism's …

Synaptic dysfunction is one of the earliest cellular defects observed in Alzheimer's disease
(AD) and Parkinson's disease (PD), occurring before widespread protein aggregation …