Glutamate is an essential excitatory neurotransmitter in the central nervous system, playing
an indispensable role in neuronal development and memory formation. The dysregulation of …

The kainic acid model of temporal lobe epilepsy has greatly contributed to the
understanding of the molecular, cellular and pharmacological mechanisms underlying …

Channelrhodopsins such as channelrhodopsin-2 (ChR2) can drive spiking with millisecond
precision in a wide variety of cells, tissues and animal species. However, several properties …

In order to understand the pathophysiology of temporal lobe epilepsy (TLE), and thus to
develop new pharmacological treatments, in vivo animal models that present features …

The whisker-to-barrel cortex is widely used to study neurovascular coupling, but the cellular
basis that underlies the perfusion changes is still largely unknown. Here, we identified …

Status epilepticus (SE) is a common neurological emergency for which new treatments are
needed. In vitro studies suggest a novel approach to controlling seizures in SE: acute …

Epilepsy is characterized by spontaneous non-provoked seizures, yet the mechanisms that
trigger a seizure and allow its evolution remain underexplored. To dissect out phases of …

Even though recent studies have suggested that seizures do not occur suddenly and that
before a seizure there is a period with an increased probability of seizure occurrence …

The hippocampal formation is crucial for the generation and regulation of several brain
functions, including memory and learning processes; however, it is vulnerable to …

Epilepsy is a multi-etiological brain dysfunction syndrome. Hippocampal neuronal damage
induced by seizures may be one of the causes leading to cognitive impairment, but the …