Pannexin 1 as a driver of inflammation and ischemia–reperfusion injury
Abstract Pannexin 1 (Panx1) is a ubiquitously expressed protein forming large conductance
channels that are central to many distinct inflammation and injury responses. There is …
channels that are central to many distinct inflammation and injury responses. There is …
Structure versus function: Are new conformations of pannexin 1 yet to be resolved?
Pannexin 1 (Panx1) plays a decisive role in multiple physiological and pathological settings,
including oxygen delivery to tissues, mucociliary clearance in airways, sepsis, neuropathic …
including oxygen delivery to tissues, mucociliary clearance in airways, sepsis, neuropathic …
Trans-Seq maps a selective mammalian retinotectal synapse instructed by Nephronectin
The mouse visual system serves as an accessible model to understand mammalian circuit
wiring. Despite rich knowledge in retinal circuits, the long-range connectivity map from …
wiring. Despite rich knowledge in retinal circuits, the long-range connectivity map from …
A rare single nucleotide variant in Pm5e confers powdery mildew resistance in common wheat
J Xie, G Guo, Y Wang, T Hu, L Wang, J Li… - New …, 2020 - Wiley Online Library
Powdery mildew poses severe threats to wheat production. The most sustainable way to
control this disease is through planting resistant cultivars. We report the map‐based cloning …
control this disease is through planting resistant cultivars. We report the map‐based cloning …
Cryo-EM structures of the ATP release channel pannexin 1
The plasma membrane adenosine triphosphate (ATP) release channel pannexin 1 (PANX1)
has been implicated in many physiological and pathophysiological processes associated …
has been implicated in many physiological and pathophysiological processes associated …
ER-resident STIM1/2 couples Ca2+ entry by NMDA receptors to pannexin-1 activation
Pannexin-1 (Panx1) is a large-pore ion and solute permeable channel highly expressed in
the nervous system, where it subserves diverse processes, including neurite outgrowth …
the nervous system, where it subserves diverse processes, including neurite outgrowth …
Pannexin 1 channels as a therapeutic target: Structure, inhibition, and outlook
KE Navis, CY Fan, T Trang, RJ Thompson… - ACS Chemical …, 2020 - ACS Publications
Pannexin 1 (Panx1) channels are transmembrane proteins that release adenosine
triphosphate and play an important role in intercellular communication. They are widely …
triphosphate and play an important role in intercellular communication. They are widely …
Skin in the game: pannexin channels in healthy and cancerous skin
BL O'Donnell, S Penuela - Biochemical Journal, 2023 - portlandpress.com
The skin is a highly organized tissue composed of multiple layers and cell types that require
coordinated cell to cell communication to maintain tissue homeostasis. In skin cancer, this …
coordinated cell to cell communication to maintain tissue homeostasis. In skin cancer, this …
Differential activation of mouse and human Panx1 channel variants
Pannexins are ubiquitously expressed in human and mouse tissues. Pannexin 1 (Panx1),
the most thoroughly characterized member of this family, forms plasmalemmal membrane …
the most thoroughly characterized member of this family, forms plasmalemmal membrane …
Pannexin 1 channels and ATP release in epilepsy: two sides of the same coin: the contribution of pannexin-1, connexins, and CALHM ATP-release channels to …
Purinergic signaling mediated by ATP and its metabolites contributes to various brain
physiological processes as well as to several pathological conditions, including …
physiological processes as well as to several pathological conditions, including …