A story of kinases and adaptors: The role of LCK, ZAP-70 and LAT in switch panel governing T-cell development and activation
LM Fernández-Aguilar, I Vico-Barranco… - Biology, 2023 - mdpi.com
Simple Summary Tyrosine phosphorylation is the first biochemical event that occurs after
TCR engagement, which is crucial for T-cell development, activation and differentiation …
TCR engagement, which is crucial for T-cell development, activation and differentiation …
Expression of Non-T Cell Activation Linker (NTAL) in Jurkat Cells Negatively Regulates TCR Signaling: Potential Role in Rheumatoid Arthritis
I Narbona-Sánchez, A Pérez-Linaza… - International Journal of …, 2023 - mdpi.com
T lymphocytes are key players in adaptive immune responses through the recognition of
peptide antigens through the T Cell Receptor (TCR). After TCR engagement, a signaling …
peptide antigens through the T Cell Receptor (TCR). After TCR engagement, a signaling …
A stretch of negatively charged amino acids of linker for activation of t-cell adaptor has a dual role in t-cell antigen receptor intracellular signaling
MM Arbulo-Echevarria, I Narbona-Sánchez… - Frontiers in …, 2018 - frontiersin.org
The adaptor protein linker for activation of T cells (LAT) has an essential role transducing
activatory intracellular signals coming from the TCR/CD3 complex. Previous reports have …
activatory intracellular signals coming from the TCR/CD3 complex. Previous reports have …
Increased Protein Stability and Interleukin-2 Production of a LATG131D Variant With Possible Implications for T Cell Anergy
MM Arbulo-Echevarria, I Vico-Barranco… - Frontiers in Cell and …, 2020 - frontiersin.org
The adaptor LAT plays a crucial role in the transduction of signals coming from the TCR/CD3
complex. Phosphorylation of some of its tyrosines generates recruitment sites for other …
complex. Phosphorylation of some of its tyrosines generates recruitment sites for other …
Use of senotherapies to decrease radiation-induced senescence and resistance in lung cancer.
A Saleh - 2024 - figshare.le.ac.uk
Lung cancer is the principal cause of oncogenic mortality, non-small cell lung cancer
(NSCLC) being the most common form. Although different treatments are available …
(NSCLC) being the most common form. Although different treatments are available …
The transmembrane adaptor protein NTAL limits mast cell chemotaxis toward prostaglandin E2
I Halova, M Bambouskova, L Draberova, V Bugajev… - Science …, 2018 - science.org
Chemotaxis of mast cells is one of the crucial steps in their development and function. Non–
T cell activation linker (NTAL) is a transmembrane adaptor protein that inhibits the activation …
T cell activation linker (NTAL) is a transmembrane adaptor protein that inhibits the activation …
Increased Protein Stability and Interleukin-2 Production of a LAT (G131D) Variant With Possible Implications for T Cell Anergy
M Martínez de Arbulo Echevarría, I Vico Barranco… - 2020 - rodin.uca.es
The adaptor LAT plays a crucial role in the transduction of signals coming from the TCR/CD3
complex. Phosphorylation of some of its tyrosines generates recruitment sites for other …
complex. Phosphorylation of some of its tyrosines generates recruitment sites for other …
a stretch of negatively charged amino acids of linker for activation of T-cell adaptor has a Dual role in T-cell antigen receptor intracellular signaling
M Martínez de Arbulo Echevarría, I Narbona Sánchez… - 2018 - rodin.uca.es
The adaptor protein linker for activation of T cells (LAT) has an essential role transducing
activatory intracellular signals coming from the TCR/CD3 complex. Previous reports have …
activatory intracellular signals coming from the TCR/CD3 complex. Previous reports have …