Background Indomethacin is used as standard therapy to close a patent ductus arteriosus
(PDA) but is associated with reduced blood flow to several organs. Ibuprofen, another cyclo …

Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly prescribed in pregnancy to
treat fever, pain and inflammation. Indications for chronic use of these agents during …

Our aim was to assess the efficacy and safety of intravenous (iv) paracetamol vs. iv
ibuprofen for the treatment of hemodynamically significant patent ductus arteriosus (hsPDA) …

All neonates in the Neonatal Intensive Care Unit (NICU) or during the first days of life
undergo painful and stressful procedures. Epidemiologic studies have shown that pain …

Abstract Background and Objectives During the newborn period and early infancy, renal
function matures, resulting in changes in the glomerular filtration rate (GFR). This study was …

BACKGROUND:: Endotracheal intubation and mechanical ventilation are major components
of routine intensive care for very low birth weight newborns and sick full-term newborns …

ABSTRACT A multicenter, double-blind, randomized, placebo-controlled trial was conducted
to evaluate the efficacy and safety of intravenous (IV) ibuprofen (L-lysine) for the early …

Patent ductus arteriosus (PDA) in preterm infants is a controversial topic in the management
of preterm neonates. There are no generally accepted guidelines for diagnosis, treatment …

Ibuprofen, a nonsteroidal antiinflammatory drug, widely used as antipyretic,
antiinflammatory, and analgesic agent and for therapy of arthritis, exerts a dose-dependent …

Over recent years, the clinical approach to patency of the ductus arteriosus in the premature
neonate has been the subject of intensive reevaluation. What had once been considered …