[HTML][HTML] Hepatitis C virus: Virology, diagnosis and treatment

HC Li, SY Lo - World journal of hepatology, 2015 - ncbi.nlm.nih.gov
More than twenty years of study has provided a better understanding of hepatitis C virus
(HCV) life cycle, including the general properties of viral RNA and proteins. This effort …

safety and tolerability of direct‐acting anti‐viral agents in the new era of hepatitis C therapy

D Banerjee, KR Reddy - Alimentary pharmacology & …, 2016 - Wiley Online Library
Background Direct‐acting anti‐virals (DAAs) licensed to treat chronic HCV infection have
revolutionised treatment algorithms by drastically mitigating side effects while enhancing …

Recent updates on viral Oncogenesis: Available preventive and therapeutic entities

S Chowdhary, R Deka, K Panda, R Kumar… - Molecular …, 2023 - ACS Publications
Human viral oncogenesis is a complex phenomenon and a major contributor to the global
cancer burden. Several recent findings revealed cellular and molecular pathways that …

Recent advancement of direct-acting antiviral agents (DAAs) in hepatitis C therapy

D Das, M Pandya - Mini Reviews in Medicinal Chemistry, 2018 - ingentaconnect.com
Hepatitis C virus (HCV) infection is a major health problem worldwide. Approximately, 170-
200 million individuals are chronically infected worldwide and a quarter of these patients are …

Cell-type-specific drug-inducible protein synthesis inhibition demonstrates that memory consolidation requires rapid neuronal translation

P Shrestha, P Ayata, P Herrero-Vidal, F Longo… - Nature …, 2020 - nature.com
New protein synthesis is known to be required for the consolidation of memories, yet existing
methods of blocking translation lack spatiotemporal precision and cell-type specificity …

Long term persistence of NS5A inhibitor‐resistant hepatitis C virus in patients who failed daclatasvir and asunaprevir therapy

S Yoshimi, M Imamura, E Murakami… - Journal of medical …, 2015 - Wiley Online Library
Although interferon‐free antiviral treatment is expected to improve treatment of hepatitis C, it
is unclear to what extent pre‐existing drug‐resistant amino acid substitutions influence …

Recent advances in antiviral therapy for chronic hepatitis C

A Tamori, M Enomoto, N Kawada - Mediators of inflammation, 2016 - Wiley Online Library
Hepatitis C virus (HCV) infection is a major worldwide health problem. Chronic infection
induces continuous inflammation in the liver, progression of hepatic fibrosis, eventual …

Repurposing drugs against the main protease of SARS-CoV-2: mechanism-based insights supported by available laboratory and clinical data

S Chakraborti, S Bheemireddy, N Srinivasan - Molecular omics, 2020 - pubs.rsc.org
The ongoing global pandemic of COVID-19 has brought life to almost a standstill with the
implementation of lockdowns and social distancing as some of the preventive measures in …

Synthetic approaches and application of clinically approved small-molecule drugs to treat hepatitis

ZX Niu, P Nie, P Herdewijn, YT Wang - European Journal of Medicinal …, 2023 - Elsevier
Hepatitis, a global public health concern, presents a significant burden on healthcare
systems worldwide. Particularly, hepatitis B and C are viral infections that can lead to severe …

Real-world efficacy and safety of pangenotypic direct-acting antivirals against hepatitis C virus infection

R Scotto, AR Buonomo, NS Moriello… - Reviews on Recent …, 2019 - ingentaconnect.com
Background: Advances in the development of Direct-Acting Antivirals (DAAs), particularly
pangenotypic drugs, have led to a high rate of hepatitis C virus (HCV) eradication. Notably …