The prevalence of obesity is increasingly common in the United States, with~ 25% of women
of reproductive age being overweight or obese. Metaflammation, a chronic low grade …

Childhood obesity and its comorbidities continue to accelerate across the globe. Two-thirds
of pregnant women are obese/overweight, as are 20% of preschoolers. Gestational diabetes …

Maternal overnutrition increases inflammatory and metabolic disease risk in postnatal
offspring. This constitutes a major public health concern due to increasing prevalence of …

Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in the United
States. Human epidemiological studies provide challenges for understanding mechanisms …

At the dawn of the twentieth century, the medical care of mothers and children was largely
relegated to family members and informally trained birth attendants. As the industrial era …

Maternal consumption of a Western-style diet (mWD) during pregnancy alters fatty acid
metabolism and reduces insulin sensitivity in fetal skeletal muscle. The long-term impact of …

Objective In humans, offspring of women who are overweight or obese are more likely to
develop metabolic disease later in life. Studies in lower animal species reveal that a …

Maternal overnutrition is associated with increased susceptibility to type 2 diabetes in the
offspring. Rodent models have shown that maternal overnutrition influences islet function in …

Malnutrition is a global threat to pregnancy health and impacts offspring development.
Establishing an optimal pregnancy environment requires the coordination of maternal …

Background In recent years, pragmatic metformin use in pregnancy has stretched to include
prediabetes mellitus, type 2 diabetes mellitus, gestational diabetes mellitus, and (most …