Adult stem cells are important for mammalian tissues, where they act as a cell reserve that
supports normal tissue turnover and can mount a regenerative response following acute …

Protein post-translational modification (PTM) is a covalent process that occurs in proteins
during or after translation through the addition or removal of one or more functional groups …

Notch signaling is an evolutionarily highly conserved signaling mechanism, but in contrast to
signaling pathways such as Wnt, Sonic Hedgehog, and BMP/TGF-β, Notch signaling occurs …

Historically, the classification and nomenclature of diseases has not been systematic and
diseases were either classified by cause, presenting symptoms and signs, pathological …

Skeletal muscle stem cells have a central role in muscle growth and regeneration. They
reside as quiescent cells in resting muscle and in response to damage they transiently …

Congenital disorders of glycosylation (CDG) are one group among the disorders of
glycosylation. The latter comprise defects associated with hypoglycosylation but also defects …

Neuromuscular disorders are a heterogeneous group of acquired or hereditary conditions
that affect striated muscle function. The resulting decrease in muscle strength and motility …

Skeletal muscle fibres are multinucleated cells that contain postmitotic nuclei (ie they are no
longer able to divide) and perform muscle contraction. They are formed by fusion of muscle …

Muscular dystrophies and congenital myopathies arise from specific genetic mutations
causing skeletal muscle weakness that reduces quality of life. Muscle health relies on …

The limb‐girdle muscular dystrophies (LGMDs) are a group of genetically heterogeneous,
autosomal inherited muscular dystrophies with a childhood to adult onset, manifesting with …