Overcoming resistance to natural killer cell based immunotherapies for solid tumors

G Nayyar, Y Chu, MS Cairo - Frontiers in oncology, 2019 - frontiersin.org
Despite advances in the diagnostic and therapeutic modalities, the prognosis of several
solid tumor malignancies remains poor. Different factors associated with solid tumors …

Natural killer cell interactions with myeloid derived suppressor cells in the tumor microenvironment and implications for cancer immunotherapy

C Zalfa, S Paust - Frontiers in Immunology, 2021 - frontiersin.org
The tumor microenvironment (TME) is a complex and heterogeneous environment
composed of cancer cells, tumor stroma, a mixture of tissue-resident and infiltrating immune …

Inhibition of IL‐6‐JAK/Stat3 signaling in castration‐resistant prostate cancer cells enhances the NK cell‐mediated cytotoxicity via alteration of PD‐L1/NKG2D ligand …

LJ Xu, XD Chen, MJ Shen, DR Yang, L Fang… - Molecular …, 2018 - Wiley Online Library
To investigate whether IL‐6 signaling affects the susceptibility of castration‐resistant
prostate cancer (CRPC) cells to cytotoxic action of natural killer (NK) cells, CRPC cell lines …

Multi-faceted immunomodulatory and tissue-tropic clinical bacterial isolate potentiates prostate cancer immunotherapy

JF Anker, AF Naseem, H Mok, AJ Schaeffer… - Nature …, 2018 - nature.com
Immune checkpoint inhibitors have not been effective for immunologically “cold” tumors,
such as prostate cancer, which contain scarce tumor infiltrating lymphocytes. We …

[HTML][HTML] Natural killer cell activity for IFN-gamma production as a supportive diagnostic marker for gastric cancer

J Lee, KH Park, JH Ryu, HJ Bae, A Choi, H Lee, J Lim… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Results NKA-IFNγ levels were decreased in 261 GC patients with all stages of tumor
compared to those in 48 healthy donors (P< 0.001), and lower levels of NKA-IFNγ were …

A high-throughput assay of NK cell activity in whole blood and its clinical application

S Lee, J Cha, I Kim, JC Yoon, HJ Lee, SW Park… - Biochemical and …, 2014 - Elsevier
Natural killer (NK) cells are lymphocytes of the innate immune system and have the ability to
kill tumor cells and virus-infected cells without prior sensitization. Malignant tumors and …

[HTML][HTML] Immunological facets of prostate cancer and the potential of immune checkpoint inhibition in disease management

SB Hansen, B Unal, OF Kuzu, F Saatcioglu - Theranostics, 2024 - pmc.ncbi.nlm.nih.gov
Prostate cancer (PCa) is the most common non-cutaneous cancer in men and a major cause
of cancer-related deaths. Whereas localized PCa can be cured by surgery and radiotherapy …

[PDF][PDF] Association between natural killer cell activity and prostate cancer: a pilot study

J Barkin, R Rodriguez-Suarez, K Betito - Can J Urol, 2017 - canjurol.com
Materials and methods: The aim of the present pilot study was to study the association
between NK cell activity (NKA) and prostate cancer using a simple blood test. Subjects that …

Natural killer cell activity as a biomarker for the diagnosis of lung cancer in high-risk patients

M Borg, SWC Wen, TF Hansen… - Journal of …, 2022 - journals.sagepub.com
Objective Natural killer (NK) cells play an essential role in the immune response against
cancer. However, immune escape mechanisms may cause inferior NK cell activity (NKA) in …

[HTML][HTML] Effect of perioperative regional anesthesia on cancer recurrence: a meta-analysis of randomized controlled trials

ZX Lee, KT Ng, E Ang, CY Wang… - International Journal of …, 2020 - Elsevier
Background Studies have reported that general anesthesia (GA), especially volatile agents
were associated with higher cancer recurrence rate after cancer resection surgery. However …