Tuberous sclerosis complex (TSC) is an autosomal dominant disorder that is characterized
by benign tumors (hamartomas and hamartias) involving multiple organ systems, due to …

Upon cell-cycle arrest or nutrient deprivation, the cellular rate of ribosome production is
reduced significantly. In mammalian cells, this effect is achieved in part through a co …

The removal of extracellular amino acids or leucine alone inhibits the ability of the
mammalian target of rapamycin (mTOR) to signal to the raptor-dependent substrates, p70 …

Extensive evidence implicates activation of the lipid phosphatidylinositide 3-kinase (PI3K)
pathway in the genesis and progression of various human cancers. PI3K inhibitors thus …

Hypoxia activates autophagy, an evolutionarily conserved cellular catabolic process.
Dysfunction in the autophagy pathway has been implicated in an increasing number of …

The insulin/IGF-activated AKT signaling pathway plays a crucial role in regulating tissue
growth and metabolism in multicellular animals. Although core components of the pathway …

The TOR kinase is a major regulator of growth in eukaryotes. Many components of the TOR
pathway are implicated in cancer and metabolic diseases in humans. Analysis of the …

The fission yeast Schizosaccharomyces pombe is an excellent model system in which to
study the coordination of cell growth and cell differentiation. In the presence of nutrients …

Mantle cell lymphoma (MCL) is characterized by the t (11; 14) and cyclin D1 overexpression.
However, additional molecular events are most likely required for oncogenesis, possibly …

Summary DNA methyltransferase DNMT3B is frequently overexpressed in tumor cells and
plays important roles during the formation and progression of several cancer types …