Germ cells play a unique role in gamete production, heredity and evolution. Therefore, to
understand the mechanisms that specify germ cells is a central challenge in developmental …

The evolutionarily conserved Argonaute/PIWI (AGO/PIWI, also known as PAZ-PIWI domain
or PPD) family of proteins is crucial for the biogenesis and function of small noncoding RNAs …

This weighty book was written with the objective of providing a summary of the practice of
Drosophila genetics and biology. The emphasis is on experimental methods, the author's …

"... but our knowledge is so weak that no philosopher will ever be able to completely explore
the nature of even a fly..."* Thomas Aquinas" In Symbolum Apostolorum" 079 RSV p/96 This …

Oncogenic activation of the proto-oncogene c-abl in human leukemias occurs as a result of
the addition of exons from the gene bcr and truncation of the first abl exon. Analysis of …

The piwi family genes, which are defined by conserved PAZ and Piwi domains, play
important roles in stem cell self-renewal, RNA silencing, and translational regulation in …

Activation of the zygotic genome is a prerequisite for the transition from maternal to zygotic
control of development. The onset of zygotic transcription has been well studied in somatic …

The oskar gene directs germ plasm assembly and controls the number of germ cell
precursors formed at the posterior pole of the Drosophila embryo. Mislocalization of oskar …

To understand the origins and function of the human germ cell lineage and to identify germ
cell-specific markers we have isolated a human ortholog of the Drosophila gene vasa. The …

Summary oskar is one of seven Drosophila maternal-effect genes that are necessary for
germline and abdomen formation. We have cloned oskar and show that oskar RNA is …