Aging is a complex process that features a functional decline in many organelles. Although
mitochondrial dysfunction is suggested as one of the determining factors of aging, the role of …

Aging, as a complex process involving multiple cellular and molecular pathways, is known to
be exacerbated by various stresses. Because responses to these stresses, such as oxidative …

There remains an unmet need to identify novel therapeutic strategies capable of protecting
the myocardium against the detrimental effects of acute ischemia–reperfusion injury (IRI), to …

Exercise-induced activation of adenosine monophosphate–activated protein kinase (AMPK)
and substrate phosphorylation modulate the metabolic capacity of mitochondria in skeletal …

AMP-activated protein kinase (AMPK) is a protein kinase that plays versatile roles in
response to a variety of physiological stresses, including glucose deprivation, hypoxia, and …

Physical activity, including walking, has numerous health benefits in older adults, supported
by a plethora of observational and interventional studies. Walking decreases the risk or …

Mitochondrial fission is a crucial process in maintaining metabolic homeostasis in normal
physiology and under conditions of stress. Its dysregulation has been associated with …

Epigenetic dysregulation emerges as a critical hallmark and driving force of aging. Although
still an evolving field with much to explore, it has rapidly gained significance by providing …

The benefits of regular physical activity are related to delaying and reversing the onset of
ageing and age-related disorders, including cardiomyopathy, neurodegenerative diseases …

The dynamicity of the mitochondrial network is crucial for meeting the ever‐changing
metabolic and energy needs of the cell. Mitochondrial fission promotes the degradation and …