Nanozymes: definition, activity, and mechanisms

M Zandieh, J Liu - Advanced materials, 2024 - Wiley Online Library
Abstract “Nanozyme” is used to describe various catalysts from immobilized inorganic metal
complexes, immobilized enzymes to inorganic nanoparticles. Here, the history of …

Biomimetic and bioorthogonal nanozymes for biomedical applications

C Keum, CM Hirschbiegel, S Chakraborty, S Jin… - Nano …, 2023 - Springer
Nanozymes mimic the function of enzymes, which drive essential intracellular chemical
reactions that govern biological processes. They efficiently generate or degrade specific …

Modular Fabrication of Bioorthogonal Nanozymes for Biomedical Applications

R Huang, CM Hirschbiegel, V Lehot, L Liu… - Advanced …, 2024 - Wiley Online Library
The incorporation of transition metal catalysts (TMCs) into nanoscaffolds generates
nanocatalysts that replicate key aspects of enzymatic behavior. The TMCs can access …

Amphiphilic polymeric nanoparticles enable homogenous rhodium-catalysed NH insertion reactions in living cells

A Sathyan, T Loman, L Deng, ARA Palmans - Nanoscale, 2023 - pubs.rsc.org
Rh-catalysed NH carbene insertion reactions were exported to living cells with help of
amphiphilic polymeric nanoparticles. Hereto, hydrophobic dirhodium carboxylate catalysts …

Modulation of Gold Nanoparticle Ligand Structure–Dynamic Relationships Probed Using Solution NMR

R Huang, S Fedeli, CM Hirschbiegel, X Zhang… - ACS Nanoscience …, 2023 - ACS Publications
Ligand dynamics plays a critical role in the chemical and biological properties of gold
nanoparticles (AuNPs). In this study, ligands featuring hydrophobic alkanethiol interiors and …

Biodegradable Antibacterial Bioorthogonal Polymeric Nanocatalysts Prepared by Flash Nanoprecipitation

S Fedeli, R Huang, Y Oz, X Zhang… - … applied materials & …, 2023 - ACS Publications
Bioorthogonal activation of pro-dyes and prodrugs using transition-metal catalysts (TMCs)
provides a promising strategy for imaging and therapeutic applications. TMCs can be loaded …

NIR-II light-activated and Cu nanocatalyst-enabled bioorthogonal reaction in living systems for efficient tumor therapy

H Huang, W Xuan, J Hai, X Wang, M Chen, G Hong… - Nano Today, 2024 - Elsevier
Bioorthogonal reaction refers to chemical reactions that occur within a biological system
without interfering the normal biochemical process, offering the unprecedented versatility in …

Controlled bioorthogonal catalyst self-assembly and activity using rationally designed polymer scaffolds

R Huang, CM Hirschbiegel, DC Luther, CH Li… - Nanoscale, 2025 - pubs.rsc.org
Polymer-based nanocatalysts have been extensively utilized in advanced drug delivery due
to their versatility and high reactivity. Incorporating bioorthogonal transition metal catalysts …

Engineering of bioorthogonal polyzymes through polymer sidechain design

CM Hirschbiegel, R Goswami… - Journal of Polymer …, 2024 - Wiley Online Library
Synthetic polymer scaffolds can encapsulate transition metal catalysts (TMCs) to provide
bioorthogonal nanocatalysts. These “polyzymes” catalyze the in situ generation of …

Nanozymes for Emerging Therapy

A Gupta, R Huang, VM Rotello - Biomedical Nanozymes: From Diagnostics …, 2023 - Springer
Bioorthogonal catalysts facilitate non-native chemical reactions without disrupting inherent
biological processes. Transition metal catalysts (TMCs) mediate bioorthogonal catalysis …