The twenty-first century has already recorded more than ten major epidemic or pandemic
virus emergence events, including the ongoing and devastating coronavirus disease 2019 …

Rotavirus infections are a leading cause of severe, dehydrating gastroenteritis in children< 5
years of age. Despite the global introduction of vaccinations for rotavirus over a decade ago …

Enteric viruses, particularly rotaviruses and noroviruses, are a leading cause of
gastroenteritis worldwide. Rotaviruses primarily affect young children, accounting for almost …

Originally developed and commercialized as an antiprotozoal agent, nitazoxanide was later
identified as a first-in-class broad-spectrum antiviral drug and has been repurposed for the …

Acute diarrhoeal diseases remain a leading cause of global morbidity and mortality
particularly among young children in resource-limited countries. Recent large studies …

Recent advances of rotavirus (RV) basic and applied research are reviewed. They consist of
determination of the RV particle structure and functions of structural proteins, classification …

Background The current outbreak of pandemic coronavirus disease 2019 (COVID-19)
aggravates serious need for effective therapeutics. Over recent years, drug repurposing has …

Viruses use a limited set of host pathways for infection. These pathways represent bona fide
antiviral targets with low likelihood of viral resistance. We identified the salicylanilide …

There is an unmet need in severe asthma where approximately 40% of patients exhibit poor
β-agonist responsiveness, suffer daily symptoms and show frequent exacerbations …

Rotavirus is the leading cause of severe childhood gastroenteritis. Each year, rotavirus is
responsible for about 25 million clinic visits, two million hospital admissions, and 180 000 …