Alteration in the expression of cell-surface proteins is a common consequence of malignant
transformation. Natural killer (NK) cells use an array of germline-encoded activating and …

During the past two decades, the paradigm for cancer treatment has evolved from relatively
nonspecific cytotoxic agents to selective, mechanism-based therapeutics. Cancer …

Epigenetics is a quickly growing field encompassing mechanisms regulating gene
expression that do not involve changes in the genotype. Epigenetics is of increasing …

Immune checkpoint inhibitors (ICI) revolutionized the field of immuno-oncology and opened
new avenues towards the development of novel assets to achieve durable immune control …

Research over the years has shown that causes of Alzheimer's disease are not well
understood, but over the past years, the involvement of epigenetic mechanisms in the …

Immune checkpoint factors, such as programmed cell death protein-1/2 (PD-1, PD-2) or
cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) receptors, are targets for monoclonal …

The gene based therapeutics and drug targets have shown incredible and appreciable
advances in alleviating human sufferings and complexities. Epigenetics simply means …

Many cancers possess the ability to suppress the immune response to malignant cells, thus
facilitating tumour growth and invasion, and this has fuelled research to reverse these …

Small cell lung cancer (SCLC) is a pulmonary neuroendocrine cancer with very poor
prognosis and limited effective therapeutic options. Most patients are diagnosed at …

The vast majority of Alzheimer's disease (AD) are late-onset forms (LOAD) likely due to the
interplay of environmental influences and individual genetic susceptibility. Epigenetic …