Over the past 40 years, there has been a strong focus on the development of mathematical
models of angiogenesis, while developmental remodelling has received little such attention …

Blood vessel regression is an essential process for ensuring blood vessel networks function
at optimal efficiency and for matching blood supply to the metabolic needs of tissues as they …

Establishment of a functional vascular network is rate-limiting in embryonic development,
tissue repair and engineering. During blood vessel formation, newly generated endothelial …

Patterning of functional blood vessel networks is achieved by pruning of superfluous
connections. The cellular and molecular principles of vessel regression are poorly …

Formation of blood vessel networks by sprouting angiogenesis is critical for tissue growth,
homeostasis and regeneration. How endothelial cells arise in adequate numbers and …

Activin receptor-like kinase 1 (ALK1) is an endothelial serine–threonine kinase receptor for
bone morphogenetic proteins (BMPs) 9 and 10. Inactivating mutations in the ALK1 gene …

Morphogenesis of the vascular system is strongly modulated by mechanical forces from
blood flow. Hereditary hemorrhagic telangiectasia (HHT) is an inherited autosomal …

Endothelial cells respond to molecular and physical forces in development and vascular
homeostasis. Deregulation of endothelial responses to flow-induced shear is believed to …

Background: Hereditary hemorrhagic telangiectasia (HHT) is an inherited vascular disorder
that causes arteriovenous malformations (AVMs). Mutations in the genes encoding Endoglin …

Sufficient blood flow to tissues relies on arterial blood vessels, but the mechanisms
regulating their development are poorly understood. Many arteries, including coronary …