Machine learning and integrative analysis of biomedical big data

B Mirza, W Wang, J Wang, H Choi, NC Chung, P Ping - Genes, 2019 - mdpi.com
Recent developments in high-throughput technologies have accelerated the accumulation
of massive amounts of omics data from multiple sources: genome, epigenome …

Are we close to defining a metabolomic signature of human obesity? A systematic review of metabolomics studies

OD Rangel-Huerta, B Pastor-Villaescusa, A Gil - Metabolomics, 2019 - Springer
Introduction Obesity is a disorder characterized by a disproportionate increase in body
weight in relation to height, mainly due to the accumulation of fat, and is considered a …

Body mass index and risk for intubation or death in SARS-CoV-2 infection: a retrospective cohort study

MR Anderson, J Geleris, DR Anderson… - Annals of internal …, 2020 - acpjournals.org
Background: Obesity is a risk factor for pneumonia and acute respiratory distress syndrome.
Objective: To determine whether obesity is associated with intubation or death …

[HTML][HTML] Profound perturbation of the metabolome in obesity is associated with health risk

ET Cirulli, L Guo, CL Swisher, N Shah, L Huang… - Cell metabolism, 2019 - cell.com
Obesity is a heterogeneous phenotype that is crudely measured by body mass index (BMI).
There is a need for a more precise yet portable method of phenotyping and categorizing risk …

Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity

JGM Markle, DN Frank, S Mortin-Toth, CE Robertson… - Science, 2013 - science.org
Microbial exposures and sex hormones exert potent effects on autoimmune diseases, many
of which are more prevalent in women. We demonstrate that early-life microbial exposures …

Insight into the prebiotic concept: lessons from an exploratory, double blind intervention study with inulin-type fructans in obese women

EM Dewulf, PD Cani, SP Claus, S Fuentes… - Gut, 2013 - gut.bmj.com
Objective To highlight the contribution of the gut microbiota to the modulation of host
metabolism by dietary inulin-type fructans (ITF prebiotics) in obese women. Methods A …

Current metabolomics: practical applications

SP Putri, Y Nakayama, F Matsuda, T Uchikata… - Journal of bioscience …, 2013 - Elsevier
The field of metabolomics continues to grow rapidly over the last decade and has been
proven to be a powerful technology in predicting and explaining complex phenotypes in …

[PDF][PDF] Metabolomic‐based noninvasive serum test to diagnose nonalcoholic steatohepatitis: results from discovery and validation cohorts

R Mayo, J Crespo, I Martínez‐Arranz… - Hepatology …, 2018 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) is the most common type of chronic liver disease
worldwide and includes a broad spectrum of histologic phenotypes, ranging from simple …

[HTML][HTML] Clusterin: Always protecting. Synthesis, function and potential issues

C Rodríguez-Rivera, MM Garcia… - Biomedicine & …, 2021 - Elsevier
In the last years, clusterin, a challenging and paradoxical apolipoprotein, has been of
growing interest amongst a rising number of scientists. This enigmatic protein is present in …

Measuring the exposome: a powerful basis for evaluating environmental exposures and cancer risk

CP Wild, A Scalbert, Z Herceg - Environmental and molecular …, 2013 - Wiley Online Library
Advances in laboratory sciences offer much in the challenge to unravel the complex etiology
of cancer and to therefore provide an evidence‐base for prevention. One area where …