For the past two decades, the function of intrabony nerves on bone has been a subject of
intense research, while the function of bone on intrabony nerves is still hidden in the corner …

Multinucleation is a hallmark of osteoclast maturation. The unique and dynamic
multinucleation process not only increases cell size but causes functional alterations …

Joint pain is the defining symptom of osteoarthritis (OA) but its origin and mechanisms
remain unclear. Here, we investigated an unprecedented role of osteoclast-initiated …

Accumulating research has shed light on the significance of skeletal interoception, in
maintaining physiological and metabolic homeostasis related to bone health. This review …

Abstract Small GTPases including Ras, Rho, Rab, Arf, and Ran are omnipresent molecular
switches in regulating key cellular functions. Their dysregulation is a therapeutic target for …

Netrin-1 is a member of the laminin-like protein family and was initially identified as a potent
chemotactic molecule involved in axonal guidance and cell migration during embryonic …

Netrins belong to the family of laminin-like secreted proteins, which guide axonal migration
and neuronal growth in the developing central nervous system. Over the last 20 years, it has …

Over the past decades, emerging evidence in the literature has demonstrated that the
innervation of bone is a crucial modulator for skeletal physiology and pathophysiology. The …

Slit/Robo signals were initially found to play an essential role in nerve development as
axonal guidance molecules. In recent years, with in-depth study, the role of Slit/Robo in …

Background Angiogenesis, the process in which new blood vessels are formed from
preexisting ones, is highly dependent on the presence of classical angiogenic factors …