This paper is the thirty-seventh consecutive installment of the annual review of research
concerning the endogenous opioid system. It summarizes papers published during 2014 …

Uses of medicinal plants by people around the world significantly contribute and guide
biologically active compounds research that can be useful in the combat against various …

Background Curcumin is one of the compounds present in plants of the genus Curcuma sp.,
being very used not only as condiment but also with medicinal purposes. As an analgesic …

Molecular mechanism of reproductive toxicity induced by Trip... : Medicine Molecular mechanism
of reproductive toxicity induced by Tripterygium Wilfordii based on network pharmacology …

Introduction Pain is an unpleasant sensation triggered by noxious stimulation. It is one of the
most prevalent conditions, limiting productivity and diminishing quality of life. Non steroidal …

Purpose Studies conducted since 1969 have shown that the release of serotonin (5-HT) in
the dorsal horn of the spinal cord contributes to opioid analgesia. In the present study, the …

BACKGROUND AND PURPOSE The synthetic peptide PnPP-19 has been studied as a new
drug candidate to treat erectile dysfunction. However, PnTx2–6, the spider toxin from which …

Substances derived from plants play an important role in the development of new analgesic
drugs, among them, triterpenoids. The connection between the participation of L …

Background. Aripiprazole is an antipsychotic drug used to treat schizophrenia and related
disorders. Our previous study showed that this compound also induces antinociceptive …

Despite all the development of modern medicine, around 100 compounds derived from
natural products were undergoing clinical trials only at the end of 2013. Among these natural …