Recent advances in deep learning for protein-protein interaction analysis: A comprehensive review

M Lee - Molecules, 2023 - mdpi.com
Deep learning, a potent branch of artificial intelligence, is steadily leaving its transformative
imprint across multiple disciplines. Within computational biology, it is expediting progress in …

Recent advances and challenges in protein structure prediction

CX Peng, F Liang, YH Xia, KL Zhao… - Journal of Chemical …, 2023 - ACS Publications
Artificial intelligence has made significant advances in the field of protein structure prediction
in recent years. In particular, DeepMind's end-to-end model, AlphaFold2, has demonstrated …

Deep transfer learning for inter-chain contact predictions of transmembrane protein complexes

P Lin, Y Yan, H Tao, SY Huang - Nature Communications, 2023 - nature.com
Membrane proteins are encoded by approximately a quarter of human genes. Inter-chain
residue-residue contact information is important for structure prediction of membrane protein …

Protein–protein contact prediction by geometric triangle-aware protein language models

P Lin, H Tao, H Li, SY Huang - Nature Machine Intelligence, 2023 - nature.com
Abstract Information regarding the residue–residue distance between interacting proteins is
important for modelling the structures of protein complexes, as well as being valuable for …

Prediction of inter-chain distance maps of protein complexes with 2D attention-based deep neural networks

Z Guo, J Liu, J Skolnick, J Cheng - Nature Communications, 2022 - nature.com
Residue-residue distance information is useful for predicting tertiary structures of protein
monomers or quaternary structures of protein complexes. Many deep learning methods …

Enhancing alphafold-multimer-based protein complex structure prediction with MULTICOM in CASP15

J Liu, Z Guo, T Wu, RS Roy, F Quadir, C Chen… - Communications …, 2023 - nature.com
Abstract To enhance the AlphaFold-Multimer-based protein complex structure prediction, we
developed a quaternary structure prediction system (MULTICOM) to improve the input fed to …

DeepHomo2. 0: improved protein–protein contact prediction of homodimers by transformer-enhanced deep learning

P Lin, Y Yan, SY Huang - Briefings in Bioinformatics, 2023 - academic.oup.com
Protein–protein interactions play an important role in many biological processes. However,
although structure prediction for monomer proteins has achieved great progress with the …

Deep graph learning of inter-protein contacts

Z Xie, J Xu - Bioinformatics, 2022 - academic.oup.com
Motivation Inter-protein (interfacial) contact prediction is very useful for in silico structural
characterization of protein–protein interactions. Although deep learning has been applied to …

Improving AlphaFold2-based protein tertiary structure prediction with MULTICOM in CASP15

J Liu, Z Guo, T Wu, RS Roy, C Chen… - Communications …, 2023 - nature.com
Abstract Since the 14th Critical Assessment of Techniques for Protein Structure Prediction
(CASP14), AlphaFold2 has become the standard method for protein tertiary structure …

A deep dilated convolutional residual network for predicting interchain contacts of protein homodimers

RS Roy, F Quadir, E Soltanikazemi, J Cheng - Bioinformatics, 2022 - academic.oup.com
Motivation Deep learning has revolutionized protein tertiary structure prediction recently.
The cutting-edge deep learning methods such as AlphaFold can predict high-accuracy …