While Nature harnesses RNA and DNA to store, read and write genetic information, the
inherent programmability, synthetic accessibility and wide functionality of these nucleic acids …

Bioconjugation chemistry has been used to prepare modified biomolecules with functions
beyond what nature intended. Central to these techniques is the development of highly …

RNA is often considered as being the vector for the transmission of genetic information from
DNA to the protein synthesis machinery. However, besides translation RNA participates in a …

Mass-spectrometry-based chemoproteomics has enabled the rapid and proteome-wide
discovery of functional and potentially'druggable'hotspots in proteins. While numerous …

The introduction of chemical modifications into long RNA molecules at specific positions for
visualization, biophysical investigations, diagnostic and therapeutic applications still …

The site‐selective modification of biomolecules has grown spectacularly in recent years. The
presence of a large number of functional groups in a biomolecule makes its chemo‐and …

Highlights•Nucleic acid-based enzymes are highly potential biosensing and therapeutic
tools.•Description of the chemical methods designed to improve the properties of these …

Chemically modified nucleosi (ti) des and functional oligonucleotides (ONs, including
therapeutic oligonucleotides, aptamer, nuclease, etc.) have been identified playing an …

RNA methyltransferases (RNA MTases) are a family of enzymes that catalyze the
methylation of RNA using the cofactor S‐adenosyl‐L‐methionine. While RNA MTases are …

Reactive RNA probes are useful for studying and identifying RNA‐binding proteins. To that
end, we designed and synthesized chloroacetamide‐linked 7‐deaza‐ATP which was a …