[HTML][HTML] Alcohol consumption and metabolic syndrome: clinical and epidemiological impact on liver disease

F Åberg, CD Byrne, CJ Pirola, V Männistö… - Journal of …, 2023 - Elsevier
Alcohol use and metabolic syndrome are highly prevalent in the population and frequently
co-exist. Both are implicated in a large range of health problems, including chronic liver …

Liver cirrhosis

P Ginès, A Krag, JG Abraldes, E Solà, N Fabrellas… - The Lancet, 2021 - thelancet.com
Cirrhosis is widely prevalent worldwide and can be a consequence of different causes, such
as obesity, non-alcoholic fatty liver disease, high alcohol consumption, hepatitis B or C …

Noninvasive proteomic biomarkers for alcohol-related liver disease

L Niu, M Thiele, PE Geyer, DN Rasmussen… - Nature Medicine, 2022 - nature.com
Alcohol-related liver disease (ALD) is a major cause of liver-related death worldwide, yet
understanding of the three key pathological features of the disease—fibrosis, inflammation …

Steatotic liver disease

M Israelsen, S Francque, EA Tsochatzis, A Krag - The Lancet, 2024 - thelancet.com
Steatotic liver disease is the overarching term for conditions characterised by abnormal lipid
accumulation in the liver (liver or hepatic steatosis). Steatotic liver disease encompasses …

Validation of the new nomenclature of steatotic liver disease in patients with a history of excessive alcohol intake: an analysis of data from a prospective cohort study

M Israelsen, N Torp, S Johansen… - The Lancet …, 2024 - thelancet.com
Background Steatotic liver disease is a new overarching term that includes metabolic
dysfunction-associated steatotic liver disease (MASLD), metabolic dysfunction and alcohol …

Low-to-moderate alcohol consumption is associated with increased fibrosis in individuals with metabolic dysfunction-associated steatotic liver disease

D Marti-Aguado, JL Calleja, E Vilar-Gomez… - Journal of …, 2024 - Elsevier
Background & Aims Both metabolic dysfunction and alcohol consumption cause steatotic
liver disease (SLD). The distinction between metabolic dysfunction-associated SLD …

Rifaximin-α for liver fibrosis in patients with alcohol-related liver disease (GALA-RIF): a randomised, double-blind, placebo-controlled, phase 2 trial

M Israelsen, BS Madsen, N Torp… - The Lancet …, 2023 - thelancet.com
Background Alcohol is the leading cause of liver-related mortality worldwide. The gut–liver
axis is considered a key driver in alcohol-related liver disease. Rifaximin-α improves gut …

MetALD: new opportunities to understand the role of alcohol in steatotic liver disease

M Israelsen, N Torp, S Johansen, M Thiele… - The Lancet …, 2023 - thelancet.com
For many years non-alcoholic fatty liver disease (NAFLD) and alcohol-related liver disease
(ALD) have been considered as two biologically and clinically distinct conditions. According …

Global prevalence, incidence, and outcomes of alcohol related liver diseases: a systematic review and meta-analysis

X Niu, L Zhu, Y Xu, M Zhang, Y Hao, L Ma, Y Li… - BMC Public Health, 2023 - Springer
Background Alcohol related liver disease (ARLD) is one of the major chronic liver diseases
worldwide. This review aimed to describe the global prevalence, incidence, and outcomes of …

Glucagon-like peptide-1 receptor agonists and risk of major adverse liver outcomes in patients with chronic liver disease and type 2 diabetes

A Wester, Y Shang, ET Grip, AA Matthews, H Hagström - Gut, 2024 - gut.bmj.com
Objective Phase II trials suggest glucagon-like peptide-1 receptor (GLP1) agonists resolve
metabolic dysfunction-associated steatohepatitis but do not affect fibrosis regression. We …