The systematic production of cells for cell therapies

DC Kirouac, PW Zandstra - Cell stem cell, 2008 - cell.com
Stem cells have emerged as the starting material of choice for bioprocesses to produce cells
and tissues to treat degenerative, genetic, and immunological disease. Translating the …

The in silico human surfaceome

D Bausch-Fluck, U Goldmann… - Proceedings of the …, 2018 - National Acad Sciences
Cell-surface proteins are of great biomedical importance, as demonstrated by the fact that
66% of approved human drugs listed in the DrugBank database target a cell-surface protein …

Proteomics of the Heart

OA Karpov, A Stotland, K Raedschelders… - Physiological …, 2024 - journals.physiology.org
Mass spectrometry-based proteomics is a sophisticated identification tool specializing in
portraying protein dynamics at a molecular level. Proteomics provides biologists with a …

A mass spectrometric-derived cell surface protein atlas

D Bausch-Fluck, A Hofmann, T Bock, AP Frei… - PloS one, 2015 - journals.plos.org
Cell surface proteins are major targets of biomedical research due to their utility as cellular
markers and their extracellular accessibility for pharmacological intervention. However …

Defining the cell surface cysteinome using two-step enrichment proteomics

T Yan, LM Boatner, L Cui, PJ Tontonoz, KM Backus - JACS Au, 2023 - ACS Publications
The plasma membrane proteome is a rich resource of functionally important and
therapeutically relevant protein targets. Distinguished by high hydrophobicity, heavy …

[HTML][HTML] High efficiency differentiation of human pluripotent stem cells to cardiomyocytes and characterization by flow cytometry

S Bhattacharya, PW Burridge, EM Kropp… - Journal of …, 2014 - pmc.ncbi.nlm.nih.gov
There is an urgent need to develop approaches for repairing the damaged heart,
discovering new therapeutic drugs that do not have toxic effects on the heart, and improving …

Cell-surface proteomics for the identification of novel therapeutic targets in cancer

L Kuhlmann, E Cummins, I Samudio… - Expert review of …, 2018 - Taylor & Francis
Introduction: Cancer is the second most common cause of death worldwide and its
heterogeneity complicates therapy. Standard cytotoxic regiments disrupt rapidly dividing …

Isolation of cell surface proteins for mass spectrometry-based proteomics

S Elschenbroich, Y Kim, JA Medin… - Expert review of …, 2010 - Taylor & Francis
Defining the cell surface proteome has profound importance for understanding cell
differentiation and cell–cell interactions, as well as numerous pathogenic abnormalities …

[图书][B] Medical nanotechnology and nanomedicine

HF Tibbals - 2017 - books.google.com
Considering the fluid nature of nano breakthroughs—and the delicate balance between
benefits and consequences as they apply to medicine—readers at all levels require a …

A cell surfaceome map for immunophenotyping and sorting pluripotent stem cells

RL Gundry, DR Riordon, Y Tarasova, S Chuppa… - Molecular & Cellular …, 2012 - ASBMB
Induction of a pluripotent state in somatic cells through nuclear reprogramming has ushered
in a new era of regenerative medicine. Heterogeneity and varied differentiation potentials …