Z-DNA and Z-RNA in human disease
A Herbert - Communications biology, 2019 - nature.com
Abstract Left-handed Z-DNA/Z-RNA is bound with high affinity by the Zα domain protein
family that includes ADAR (a double-stranded RNA editing enzyme), ZBP1 and viral …
family that includes ADAR (a double-stranded RNA editing enzyme), ZBP1 and viral …
The structural diversity of artificial genetic polymers
Synthetic genetics is a subdiscipline of synthetic biology that aims to develop artificial
genetic polymers (also referred to as xeno-nucleic acids or XNAs) that can replicate in vitro …
genetic polymers (also referred to as xeno-nucleic acids or XNAs) that can replicate in vitro …
Adenosine-to-inosine editing of endogenous Z-form RNA by the deaminase ADAR1 prevents spontaneous MAVS-dependent type I interferon responses
Nucleic acids are powerful triggers of innate immunity and can adopt the Z-conformation, an
unusual left-handed double helix. Here, we studied the biological function (s) of Z-RNA …
unusual left-handed double helix. Here, we studied the biological function (s) of Z-RNA …
A high-resolution atlas of nucleosome occupancy in yeast
We present the first complete high-resolution map of nucleosome occupancy across the
whole Saccharomyces cerevisiae genome, identifying over 70,000 positioned nucleosomes …
whole Saccharomyces cerevisiae genome, identifying over 70,000 positioned nucleosomes …
Permanganate/S1 nuclease footprinting reveals non-B DNA structures with regulatory potential across a mammalian genome
F Kouzine, D Wojtowicz, L Baranello, A Yamane… - Cell systems, 2017 - cell.com
DNA in cells is predominantly B-form double helix. Though certain DNA sequences in vitro
may fold into other structures, such as triplex, left-handed Z form, or quadruplex DNA, the …
may fold into other structures, such as triplex, left-handed Z form, or quadruplex DNA, the …
Crystal structure of a junction between B-DNA and Z-DNA reveals two extruded bases
SC Ha, K Lowenhaupt, A Rich, YG Kim, KK Kim - Nature, 2005 - nature.com
Left-handed Z-DNA is a higher-energy form of the double helix, stabilized by negative
supercoiling generated by transcription or unwrapping nucleosomes. Regions near the …
supercoiling generated by transcription or unwrapping nucleosomes. Regions near the …
Z-DNA formation in promoters conserved between human and mouse are associated with increased transcription reinitiation rates
A long-standing question concerns the role of Z-DNA in transcription. Here we use a deep
learning approach DeepZ that predicts Z-flipons based on DNA sequence, structural …
learning approach DeepZ that predicts Z-flipons based on DNA sequence, structural …
Microhomology-Mediated Mechanisms Underlie Non-Recurrent Disease-Causing Microdeletions of the FOXL2 Gene or Its Regulatory Domain
H Verdin, B D'haene, D Beysen, Y Novikova… - PLoS …, 2013 - journals.plos.org
Genomic disorders are often caused by recurrent copy number variations (CNVs), with
nonallelic homologous recombination (NAHR) as the underlying mechanism. Recently …
nonallelic homologous recombination (NAHR) as the underlying mechanism. Recently …
ALU non-B-DNA conformations, flipons, binary codes and evolution
A Herbert - Royal Society Open Science, 2020 - royalsocietypublishing.org
ALUs contribute to genetic diversity by altering DNA's linear sequence through
retrotransposition, recombination and repair. ALUs also have the potential to form alternative …
retrotransposition, recombination and repair. ALUs also have the potential to form alternative …
Cooperative activity of BRG1 and Z-DNA formation in chromatin remodeling
The mammalian genome contains tens of thousands of CG and TG repeat sequences that
have high potential to form the nonclassical left-handed double-helical Z-DNA structure …
have high potential to form the nonclassical left-handed double-helical Z-DNA structure …