Ethnopharmacological relevance With high mortality and morbidity rates, lung cancer (LC)
has become one of the major threats to human health. The treatment strategies for LC …

Oxymatrine (OMT), was identified as a quinolizidine alkaloid, which was one of the major
matrine-type alkaloids extracted from Sophora medicinal plants. Growing studies revealed …

Sophora is deemed as one of the most remarkable genera of Fabaceae, and the third
largest family of flowering plants. The genus Sophora comprises approximately 52 species …

Cancer-associated fibroblasts (CAFs) deteriorate tumor microenvironment (TME) and hinder
intra-tumoral drug delivery. Direct depleting CAFs exists unpredictable risks of tumor …

Lung cancer accounts for the majority of cancer-related deaths globally. Exploring more
efficacious and low-toxicity treatments has become a top priority. While there have been …

Cholesterol metabolism affects endoplasmic reticulum (ER) stress and modulates epithelial-
mesenchymal transition (EMT). Our previous study demonstrated that 2-hydroxypropyl-β …

Lappaconitine sulfate (LS) has good solubility and bioavailability. We have previously
studied the anti-proliferative activity of LS on colon cancer HT-29 cell, but its anti-proliferative …

Cancer remains a major cause of death and a severe threat to improve life span around the
world. Although the cancer treatments have made great progress, the therapeutic outcomes …

In the present review, we updated current information on the chemistry, contents, and
anticancer properties of matrine (MT), oxymatrine (OMT), and compound Kushen injection …

Background: Oxymatrine is known as one of the most promising alkaloids from Sophora
flavescens for its excellent pharmacological effects. Objective: The aim of this research is to …