T‐cell exhaustion in HIV infection

C Fenwick, V Joo, P Jacquier, A Noto… - Immunological …, 2019 - Wiley Online Library
The T‐cell response is central in the adaptive immune‐mediated elimination of pathogen‐
infected and/or cancer cells. This activated T‐cell response can inflict an overwhelming …

Aging of the immune system: focus on inflammation and vaccination

M Pinti, V Appay, J Campisi, D Frasca… - European journal of …, 2016 - Wiley Online Library
Major advances in preventing, delaying, or curing individual pathologies are responsible for
an increasingly long life span in the developed parts of our planet, and indeed reaching …

Systemic effects of inflammation on health during chronic HIV infection

SG Deeks, R Tracy, DC Douek - Immunity, 2013 - cell.com
Combination antiretroviral therapy for HIV infection improves immune function and
eliminates the risk of AIDS-related complications but does not restore full health. HIV …

HIV-infected individuals with low CD4/CD8 ratio despite effective antiretroviral therapy exhibit altered T cell subsets, heightened CD8+ T cell activation, and increased …

S Serrano-Villar, T Sainz, SA Lee, PW Hunt… - PLoS …, 2014 - journals.plos.org
A low CD4/CD8 ratio in elderly HIV-uninfected adults is associated with increased morbidity
and mortality. A subset of HIV-infected adults receiving effective antiretroviral therapy (ART) …

Sharing CD4+ T cell loss: when COVID-19 and HIV collide on immune system

X Peng, J Ouyang, S Isnard, J Lin… - Frontiers in …, 2020 - frontiersin.org
COVID-19 is a distinctive infection characterized by elevated inter-human transmission and
presenting from absence of symptoms to severe cytokine storm that can lead to dismal …

Guidelines for the use of flow cytometry and cell sorting in immunological studies

A Cossarizza, HD Chang, A Radbruch… - European journal of …, 2021 - Wiley Online Library
The third edition of Flow Cytometry Guidelines provides the key aspects to consider when
performing flow cytometry experiments and includes comprehensive sections describing …

TIGIT marks exhausted T cells, correlates with disease progression, and serves as a target for immune restoration in HIV and SIV infection

GM Chew, T Fujita, GM Webb, BJ Burwitz, HL Wu… - PLoS …, 2016 - journals.plos.org
HIV infection induces phenotypic and functional changes to CD8+ T cells defined by the
coordinated upregulation of a series of negative checkpoint receptors that eventually result …

Paths to stemness: building the ultimate antitumour T cell

L Gattinoni, CA Klebanoff, NP Restifo - Nature Reviews Cancer, 2012 - nature.com
Stem cells are defined by the ability to self-renew and to generate differentiated progeny,
qualities that are maintained by evolutionarily conserved pathways that can lead to cancer …

HIV‐associated chronic immune activation

M Paiardini, M Müller‐Trutwin - Immunological reviews, 2013 - Wiley Online Library
Systemic chronic immune activation is considered today as the driving force of CD 4+ T‐cell
depletion and acquired immunodeficiency syndrome (AIDS). A residual chronic immune …

Immune activation and HIV persistence: implications for curative approaches to HIV infection

NR Klatt, N Chomont, DC Douek… - Immunological …, 2013 - Wiley Online Library
Despite complete or near‐complete suppression of human immunodeficiency virus (HIV)
replication with combination antiretroviral therapy, both HIV and chronic …