The extracellular matrix as a multitasking player in disease

AD Theocharis, D Manou, NK Karamanos - The FEBS journal, 2019 - Wiley Online Library
Extracellular matrices (ECM s) are highly specialized and dynamic three‐dimensional (3D)
scaffolds into which cells reside in tissues. ECM is composed of a variety of fibrillar …

The nature and biology of basement membranes

A Pozzi, PD Yurchenco, RV Iozzo - Matrix Biology, 2017 - Elsevier
Basement membranes are delicate, nanoscale and pliable sheets of extracellular matrices
that often act as linings or partitions in organisms. Previously considered as passive …

[图书][B] Paller and Mancini-Hurwitz Clinical Pediatric Dermatology E-Book: A textbook of skin disorders of childhood and adolescence

AS Paller, AJ Mancini - 2020 - books.google.com
Written by two leaders in the field of pediatric dermatology, this classic text provides both
detailed content for the specialist and easily accessible information for the non …

The triple helix of collagens–an ancient protein structure that enabled animal multicellularity and tissue evolution

AL Fidler, SP Boudko, A Rokas… - Journal of cell …, 2018 - journals.biologists.com
The cellular microenvironment, characterized by an extracellular matrix (ECM), played an
essential role in the transition from unicellularity to multicellularity in animals (metazoans) …

Basement membrane collagens and disease mechanisms

A Gatseva, YY Sin, G Brezzo… - Essays in …, 2019 - portlandpress.com
Basement membranes (BMs) are specialised extracellular matrix (ECM) structures and
collagens are a key component required for BM function. While collagen IV is the major BM …

Epidermolysis bullosa: Molecular pathology of connective tissue components in the cutaneous basement membrane zone

C Has, A Nyström, AH Saeidian, L Bruckner-Tuderman… - Matrix Biology, 2018 - Elsevier
Epidermolysis bullosa (EB), a group of heritable skin fragility disorders, is characterized by
blistering, erosions and chronic ulcers in the skin and mucous membranes. In some forms …

Integrins: an important link between angiogenesis, inflammation and eye diseases

M Mrugacz, A Bryl, M Falkowski, K Zorena - Cells, 2021 - mdpi.com
Integrins belong to a group of cell adhesion molecules (CAMs) which is a large group of
membrane-bound proteins. They are responsible for cell attachment to the extracellular …

Clinical and genetic update of corneal dystrophies

W Lisch, JS Weiss - Experimental eye research, 2019 - Elsevier
Abstract The International Committee for Classification of Corneal Dystrophies (IC3D)
distinguishes between 22 distinct forms of corneal dystrophy which are predominantly …

Corneal regeneration using gene therapy approaches

S Sarkar, P Panikker, S D'Souza, R Shetty, RR Mohan… - Cells, 2023 - mdpi.com
One of the most remarkable advancements in medical treatments of corneal diseases in
recent decades has been corneal transplantation. However, corneal transplants, including …

[HTML][HTML] Integrin: Basement membrane adhesion by corneal epithelial and endothelial cells

TB McKay, U Schlötzer-Schrehardt, S Pal-Ghosh… - Experimental eye …, 2020 - Elsevier
Integrins mediate adhesion of cells to substrates and maintain tissue integrity by facilitating
mechanotransduction between cells, the extracellular matrix, and gene expression in the …