Osteoporosis is a systemic and degenerative disease characterized by low bone mass and
fragile microarchitecture, which predispose patients to fragility fractures, also known as …

Rapid advancements in traditional bone tissue engineering have led to innovation in bone
repair models and the resolution of insurmountable clinical issues like graft scarcity. The …

The regeneration of hierarchical osteochondral units is challenging due to difficulties in
inducing spatial, directional and controllable differentiation of mesenchymal stem cells …

Bone marrow-derived mesenchymal stem cells (BM-MSCs) play a crucial role in stem cell
therapy and are extensively used in regenerative medicine research. However, current …

Hematopoietic stem cell transplantation (HSCT) is a well‐established method for a variety of
acquired and congenital diseases. However, the limited number and sources of therapeutic …

The oral and maxillofacial region comprises a variety of organs made up of multiple soft and
hard tissue, which are anatomically vulnerable to the pathogenic factors of trauma …

The immunomodulatory function of mesenchymal stem cells (MSCs) is plastic and
susceptible to resident microenvironment in vivo or inflammatory factors in vitro. We propose …

Bone organoids are emerging as powerful tools for studying bone development and related
diseases. However, the simplified design of current methods somewhat limits their …

Bone diseases such as osteoporosis and osteoarthritis have become important human
health problems, requiring a deeper understanding of the pathogenesis of related diseases …

Tissue damage and functional abnormalities in organs have become a considerable clinical
challenge. Organoids are often applied as disease models and in drug discovery and …