Solid-state nuclear magnetic resonance (SSNMR) spectroscopy elucidates membrane
protein structures and dynamics in atomic detail to yield mechanistic insights. By …

Influenza A virus (IAV) matrix protein 2 (M2) is among the smallest bona fide, hence
extensively studied, ion channel proteins. The M2 ion channel activity is not only essential …

The influenza M2 protein not only forms a proton channel but also mediates membrane
scission in a cholesterol-dependent manner to cause virus budding and release. The atomic …

One of the fundamental features of biomembranes is the ability to fuse or to separate. These
processes called respectively membrane fusion and fission are central in the homeostasis of …

Membrane proteins possess a variety of functions essential to the survival of organisms.
However, due to their inherent hydrophobic nature, it is extremely difficult to probe the …

We present a general strategy for determining the cholesterol-binding site of eukaryotic
membrane proteins in native-like lipid membranes by NMR spectroscopy. The strategy …

Site‐directed spin labeling (SDSL) in combination with electron paramagnetic resonance
(EPR) spectroscopy is a rapidly expanding powerful biophysical technique to study the …

The M2 proton channel aids in the exit of mature influenza viral particles from the host
plasma membrane through its ability to stabilize regions of high negative Gaussian …

The influenza A matrix 2 (M2) transmembrane protein facilitates virion release from the
infected host cell. In particular, M2 plays a role in the induction of membrane curvature …

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) envelope (E) protein
forms a pentameric ion channel in the lipid membrane of the endoplasmic reticulum Golgi …