Emerging trends in colorectal cancer: Dysregulated signaling pathways
R Ahmad, JK Singh, A Wunnava… - International …, 2021 - spandidos-publications.com
Colorectal cancer (CRC) is the third most frequently detected type of cancer, and the second
most common cause of cancer-related mortality globally. The American Cancer Society …
most common cause of cancer-related mortality globally. The American Cancer Society …
Birth cohort colorectal cancer (CRC): implications for research and practice
Colorectal cancer (CRC) epidemiology is changing due to a birth cohort effect, first
recognized by increasing incidence of early onset CRC (EOCRC, age< 50 years). In this …
recognized by increasing incidence of early onset CRC (EOCRC, age< 50 years). In this …
Germline genetic features of young individuals with colorectal cancer
Background & Aims The incidence of colorectal cancer (CRC) in individuals younger than
50 years is increasing. We sought to ascertain the proportion of young CRC cases …
50 years is increasing. We sought to ascertain the proportion of young CRC cases …
Inherited DNA-repair defects in colorectal cancer
SH AlDubayan, M Giannakis, ND Moore… - The American Journal of …, 2018 - cell.com
Colorectal cancer (CRC) heritability has been estimated to be around 30%. However,
mutations in the known CRC-susceptibility genes explain CRC risk in fewer than 10% of …
mutations in the known CRC-susceptibility genes explain CRC risk in fewer than 10% of …
Trends in early-onset vs late-onset colorectal cancer incidence by race/ethnicity in the United States Cancer Statistics Database
SH Chang, N Patel, M Du, PS Liang - Clinical Gastroenterology and …, 2022 - Elsevier
Background & Aims Colorectal cancer (CRC) incidence has decreased overall in the last
several decades, but it has increased among younger adults. Prior studies have …
several decades, but it has increased among younger adults. Prior studies have …
Clinical characteristics of patients with colorectal cancer with double somatic mismatch repair mutations compared with Lynch syndrome
R Pearlman, S Haraldsdottir… - Journal of medical …, 2019 - jmg.bmj.com
Background Patients with colorectal cancer (CRC) with mismatch repair-deficient (dMMR)
tumours without MLH1 methylation or germline MMR pathogenic variants (PV) were …
tumours without MLH1 methylation or germline MMR pathogenic variants (PV) were …
Collaborative Group of the Americas on Inherited Gastrointestinal Cancer Position statement on multigene panel testing for patients with colorectal cancer and/or …
Multigene panel tests for hereditary cancer syndromes are increasingly utilized in the care of
colorectal cancer (CRC) and polyposis patients. However, widespread availability of panels …
colorectal cancer (CRC) and polyposis patients. However, widespread availability of panels …
NCOA1/2/3 rearrangements in uterine tumor resembling ovarian sex cord tumor: a clinicopathological and molecular study of 18 cases
B Lu, Y Xia, J Chen, J Tang, Y Shao, W Yu - Human Pathology, 2023 - Elsevier
Summary Recurrent NCOA1/2/3 gene fusions emerged in uterine tumor resembling ovarian
sex cord tumor (UTROSCT). More cases are required to consolidate these molecular …
sex cord tumor (UTROSCT). More cases are required to consolidate these molecular …
Half of germline pathogenic and likely pathogenic variants found on panel tests do not fulfil NHS testing criteria
T Andoni, J Wiggins, R Robinson, R Charlton… - Scientific Reports, 2022 - nature.com
Genetic testing for cancer predisposition has been curtailed by the cost of sequencing, and
testing has been restricted by eligibility criteria. As the cost of sequencing decreases, the …
testing has been restricted by eligibility criteria. As the cost of sequencing decreases, the …
Systematic functional interrogation of genes in GWAS loci identified ATF1 as a key driver in colorectal cancer modulated by a promoter-enhancer interaction
Genome-wide association studies (GWASs) have identified approximately 100 colorectal
cancer (CRC) risk loci. However, the causal genes in these loci have not been …
cancer (CRC) risk loci. However, the causal genes in these loci have not been …