The schizophrenia syndrome, circa 2024: What we know and how that informs its nature

R Tandon, H Nasrallah, S Akbarian… - Schizophrenia …, 2024 - Elsevier
With new data about different aspects of schizophrenia being continually generated, it
becomes necessary to periodically revisit exactly what we know. Along with a need to review …

[HTML][HTML] Epigenetics in psychiatry: Beyond DNA methylation

K Kouter, IŠ Arčan, AV Paska - World Journal of Psychiatry, 2023 - ncbi.nlm.nih.gov
The global burden of psychopathologies appears to be underestimated, since the global
psychiatric disorder burden is exceeding other medical burdens. To be able to address this …

A multi-regional human brain atlas of chromatin accessibility and gene expression facilitates promoter-isoform resolution genetic fine-mapping

P Dong, L Song, J Bendl, R Misir, Z Shao… - Nature …, 2024 - nature.com
Brain region-and cell-specific transcriptomic and epigenomic features are associated with
heritability for neuropsychiatric traits, but a systematic view, considering cortical and …

Interaction of the pre-and postnatal environment in the maternal immune activation model

A Gundacker, L Cuenca Rico, P Stoehrmann… - Discover mental …, 2023 - Springer
Adverse influences during pregnancy are associated with a range of unfavorable outcomes
for the developing offspring. Maternal psychosocial stress, exposure to infections and …

[PDF][PDF] Unmasking schizophrenia: synaptic pruning in adolescence reveals a latent physiological vulnerability in prefrontal recurrent networks

MV Chafee, BB Averbeck - Biological psychiatry, 2022 - Elsevier
Theories of the pathophysiology in schizophrenia are converging on the synapse. This
special issue collects papers from leading researchers that suggest a hypothesis that …

The 3D Genome in Brain Development: An Exploration of Molecular Mechanisms and Experimental Methods

S Rahman, P Roussos - Neuroscience Insights, 2024 - journals.sagepub.com
The human brain contains multiple cell types that are spatially organized into functionally
distinct regions. The proper development of the brain requires complex gene regulation …

Transcriptome and chromatin accessibility landscapes across 25 distinct human brain regions expand the susceptibility gene set for neuropsychiatric disorders

P Dong, J Bendl, R Misir, Z Shao, J Edelstien, DA Davis… - BioRxiv, 2022 - biorxiv.org
Brain region-and cell-specific transcriptomic and epigenomic molecular features are
associated with heritability for neuropsychiatric traits, but a systematic view, considering …

Single-nucleus transcriptome-wide association study of human brain disorders

S Venkatesh, Z Wu, M Anyfantakis, C Dillard… - medRxiv, 2024 - medrxiv.org
Neuropsychiatric and neurodegenerative disorders exhibit cell–type–specific characteristics
1–8, yet most transcriptome–wide association studies have been constrained by the use of …

Using Nonhuman Primate Models to Reverse-Engineer Prefrontal Circuit Failure Underlying Cognitive Deficits in Schizophrenia

MV Chafee - … Functioning in Schizophrenia: Leveraging the RDoC …, 2023 - Springer
In this chapter, I review studies in nonhuman primates that emulate the circuit failure in
prefrontal cortex responsible for working memory and cognitive control deficits in …

[PDF][PDF] DiscoverMental Health

A Gundacker, LC Rico, P Stoehrmann, KE Tillmann… - Discover, 2023 - researchgate.net
Adverse influences during pregnancy are associated with a range of unfavorable outcomes
for the developing offspring. Maternal psychosocial stress, exposure to infections and …