Ca2+ plays a crucial role in connecting membrane excitability with contraction in
myocardium. The hallmark features of heart failure are mechanical dysfunction and …

Ventricular remodelling describes structural changes in the left ventricle in response to
chronic alterations in loading conditions, with three major patterns: concentric remodelling …

Background In patients with severe heart failure, prolonged unloading of the myocardium
with the use of a left ventricular assist device has been reported to lead to myocardial …

This review provides a comprehensive overview of the past 25+ years of research into the
development of left ventricular assist device (LVAD) to improve clinical outcomes in patients …

Background—Myocardial recovery after left ventricular assist device (LVAD) support has
been reported. The LVAD Working Group Recovery Study was a prospective multicenter trial …

Aims Crosstalk between cardiomyocytes and fibroblasts in physiological conditions and
during disease remains poorly defined. Previous studies have shown that fibroblasts and …

In mammalian cardiac myocytes, the plasma membrane includes the surface sarcolemma
but also a network of membrane invaginations called transverse (t-) tubules. These …

Heart failure is associated with remodeling that consists of adverse cellular, structural, and
functional changes in the myocardium. Until recently, this was thought to be unidirectional …

Over the last 2 decades, numerous advancements in medical therapies have improved
patient outcomes in heart failure (HF). However, a significant number of patients still …

BACKGROUND: With improved technology, increasing clinical experience, and expanding
indications for use, left ventricular assist devices (LVADs) are assuming a greater role in the …