The tumour microenvironment (TME) is a complex system composed of cancer cells, stromal
cells and immune cells. Regulatory T cells (Tregs) in the TME impede immune surveillance …

Sfanos KS & De Marzo AM (2012) Histopathology 60, 199–215 Prostate cancer and
inflammation: the evidence Chronic inflammation is now known to contribute to several …

Glioblastoma (GBM) is the most devastating brain tumor, with associated poor prognosis.
Despite advances in surgery and chemoradiation, the survival of afflicted patients has not …

Purpose: In glioma—in contrast to various other cancers—the impact of T-lymphocytes on
clinical outcome is not clear. We investigated the clinical relevance and regulation of T-cell …

Background Tumor-infiltrating T cells are associated with survival in epithelial ovarian
cancer (EOC), but their functional status is poorly understood, especially relative to the …

To metastasize, a tumor cell must acquire abilities such as the capacity to colonize new
tissue and evade immune surveillance. Recent evidence suggests that microRNAs can …

Expression of the transcription factor FOXP3 characterizes regulatory T cells (Tregs) that
engage in the maintenance of immunological self-tolerance and immune homeostasis. Intra …

Substantial evidence indicates that gastric microbiota dysbiosis, immune system dysfunction
especially immune escape are critical for gastric cancer (GC) occurrence and progression …

Celiac disease (CD) and type 1 diabetes (T1D) are autoimmune conditions in which dietary
gluten has been proven or suggested to play a pathogenic role. In CD; gluten is established …

The forkhead box protein 3 (FOXP3) transcription factor is highly expressed in tumor cells as
well as in regulatory T cells (Tregs). It plays a tumor-enhancing role in Tregs and suppresses …