The role of oxidative stress in the aging heart

LU Pagan, MJ Gomes, M Gatto, GAF Mota, K Okoshi… - Antioxidants, 2022 - mdpi.com
Medical advances and the availability of diagnostic tools have considerably increased life
expectancy and, consequently, the elderly segment of the world population. As age is a …

Radical oxygen species: an important breakthrough point for botanical drugs to regulate oxidative stress and treat the disorder of glycolipid metabolism

M Luo, Y Zheng, S Tang, L Gu, Y Zhu, R Ying… - Frontiers in …, 2023 - frontiersin.org
Background: The incidence of glycolipid metabolic diseases is extremely high worldwide,
which greatly hinders people's life expectancy and patients' quality of life. Oxidative stress …

Protective effects of medicinal plant against diabetes induced cardiac disorder: A review

S Shabab, Z Gholamnezhad… - Journal of …, 2021 - Elsevier
Ethnopharmacology relevance Nowadays, there is an increase in global tendency to use
medicinal plants as preventive and therapeutic agents to manage diabetes and its long-term …

Pharmacology of apocynin: a natural acetophenone

SR Savla, AP Laddha, YA Kulkarni - Drug metabolism reviews, 2021 - Taylor & Francis
Apocynin is a naturally occurring acetophenone, found in the roots of Apocynum
cannabinum and Picrorhiza kurroa. Various chemical and pharmaceutical modifications …

NADPH oxidases in diastolic dysfunction and heart failure with preserved ejection fraction

JP Teuber, K Essandoh, SL Hummel, NR Madamanchi… - Antioxidants, 2022 - mdpi.com
Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases regulate production of
reactive oxygen species (ROS) that cause oxidative damage to cellular components but also …

Edaravone and acetovanillone upregulate Nrf2 and PI3K/Akt/mTOR signaling and prevent cyclophosphamide cardiotoxicity in rats

EHM Hassanein, OAM Abd El-Ghafar… - Drug Design …, 2020 - Taylor & Francis
Introduction Cyclophosphamide (CP) causes redox imbalance and its use is associated with
marked cardiotoxicity that limits its clinical applications. The present study investigated the …

Acetovanillone prevents cyclophosphamide‐induced acute lung injury by modulating PI3K/Akt/mTOR and Nrf2 signaling in rats

OAM Abd El‐Ghafar, EHM Hassanein… - Phytotherapy …, 2021 - Wiley Online Library
Cyclophosphamide (CP) is a medication used as an anticancer drug and to suppress the
immune system. However, its clinical applications are restricted because of the toxic and …

Ayurvedic Medicinal Plants Against COVID-19: An In Silico Analysis

BK Khuntia, V Sharma, S Qazi, S Das… - Natural Product …, 2021 - journals.sagepub.com
Even after one and a half years since the outbreak of COVID-19, its complete and effective
control is still far from being achieved despite vaccination drives, symptomatic management …

[HTML][HTML] Drp1-dependent mitochondrial fission mediates corneal injury induced by alkali burn

K Zhang, MY Guo, QG Li, XH Wang, YY Wan… - Free Radical Biology …, 2021 - Elsevier
Corneal alkali burn, one of the most serious ophthalmic emergencies, is difficult to be cured
by conservative treatments. It is well known that oxidative stress, inflammation and …

The effects of folic acid administration on cardiac oxidative stress and cardiovascular biomarkers in diabetic rats

S Mutavdzin, K Gopcevic, S Stankovic… - Oxidative medicine …, 2019 - Wiley Online Library
The aim of this study was to examine the effects of folic acid administration on the
antioxidant enzyme (superoxide dismutase (SOD) and catalase (CAT)) activities, lactate and …