Intracellular delivery by membrane disruption: mechanisms, strategies, and concepts

MP Stewart, R Langer, KF Jensen - Chemical reviews, 2018 - ACS Publications
Intracellular delivery is a key step in biological research and has enabled decades of
biomedical discoveries. It is also becoming increasingly important in industrial and medical …

Fluorinated carbohydrates for 18 F-positron emission tomography (PET)

E Campbell, C Jordan, R Gilmour - Chemical Society Reviews, 2023 - pubs.rsc.org
Carbohydrate diversity is foundational in the molecular literacy that regulates cellular
function and communication. Consequently, delineating and leveraging this structure …

Multifunctional nanoagents for ultrasensitive imaging and photoactive killing of Gram-negative and Gram-positive bacteria

J Tang, B Chu, J Wang, B Song, Y Su, H Wang… - Nature …, 2019 - nature.com
Simultaneous imaging and treatment of infections remains a major challenge, with most
current approaches being effective against only one specific group of bacteria or not being …

Maltodextrin-based imaging probes detect bacteria in vivo with high sensitivity and specificity

X Ning, S Lee, Z Wang, D Kim, B Stubblefield… - Nature materials, 2011 - nature.com
The diagnosis of bacterial infections remains a major challenge in medicine. Although
numerous contrast agents have been developed to image bacteria, their clinical impact has …

Towards a medically approved technology for alginate-based microcapsules allowing long-term immunoisolated transplantation

H Zimmermann, D Zimmermann, R Reuss… - Journal of materials …, 2005 - Springer
The concept of encapsulated-cell therapy is very appealing, but in practice a great deal of
technology and know-how is needed for the production of long-term functional transplants …

Intracellular delivery of trehalose for cell banking

S Stewart, X He - Langmuir, 2018 - ACS Publications
Advances in stem cell technology and regenerative medicine have underscored the need for
effective banking of living cells. Cryopreservation, using very low temperatures to achieve …

PET imaging of bacterial infections with fluorine‐18‐labeled maltohexaose

X Ning, W Seo, S Lee, K Takemiya… - Angewandte Chemie …, 2014 - Wiley Online Library
A positron emission tomography (PET) tracer composed of 18F‐labeled maltohexaose
(MH18F) can image bacteria in vivo with a sensitivity and specificity that are orders of …

Nanoparticle-mediated intracellular delivery enables cryopreservation of human adipose-derived stem cells using trehalose as the sole cryoprotectant

W Rao, H Huang, H Wang, S Zhao… - … applied materials & …, 2015 - ACS Publications
In this study, pH responsive genipin-cross-linked Pluronic F127-chitosan nanoparticles
(GNPs) was synthesized to encapsulate trehalose for intracellular delivery to cryopreserve …

Tumor growth dynamics: insights into evolutionary processes

IA Rodriguez-Brenes, NL Komarova… - Trends in ecology & …, 2013 - cell.com
Identifying the types of event that drive tumor evolution and progression is crucial for
understanding cancer. We suggest that the analysis of tumor growth dynamics can provide a …

Cold-responsive nanoparticle enables intracellular delivery and rapid release of trehalose for organic-solvent-free cryopreservation

Y Zhang, H Wang, S Stewart, B Jiang, W Ou, G Zhao… - Nano …, 2019 - ACS Publications
Conventional cryopreservation of mammalian cells requires the use of toxic organic solvents
(eg, dimethyl sulfoxide) as cryoprotectants. Consequently, the cryopreserved cells must …