The Candida pathogenic species complex

SA Turner, G Butler - Cold Spring Harbor …, 2014 - perspectivesinmedicine.cshlp.org
Candida species are the most common causes of fungal infection. Approximately 90% of
infections are caused by five species: Candida albicans, Candida glabrata, Candida …

[HTML][HTML] Drug resistance and novel therapeutic approaches in invasive candidiasis

SE Murphy, T Bicanic - Frontiers in cellular and infection microbiology, 2021 - frontiersin.org
Candida species are the leading cause of invasive fungal infections worldwide and are
associated with acute mortality rates of~ 50%. Mortality rates are further augmented in the …

Components of the calcium-calcineurin signaling pathway in fungal cells and their potential as antifungal targets

S Liu, Y Hou, W Liu, C Lu, W Wang, S Sun - Eukaryotic cell, 2015 - Am Soc Microbiol
In recent years, the emergence of fungal resistance has become frequent, partly due to the
widespread clinical use of fluconazole, which is minimally toxic and effective in the …

Calcineurin Plays Key Roles in the Dimorphic Transition and Virulence of the Human Pathogenic Zygomycete Mucor circinelloides

SC Lee, A Li, S Calo, J Heitman - PLoS pathogens, 2013 - journals.plos.org
Many pathogenic fungi are dimorphic and switch between yeast and filamentous states. This
switch alters host-microbe interactions and is critical for pathogenicity. However, in …

Calcineurin in fungal virulence and drug resistance: Prospects for harnessing targeted inhibition of calcineurin for an antifungal therapeutic approach

PR Juvvadi, SC Lee, J Heitman, WJ Steinbach - Virulence, 2017 - Taylor & Francis
Increases in the incidence and mortality due to the major invasive fungal infections such as
aspergillosis, candidiasis and cryptococcosis caused by the species of Aspergillus, Candida …

Calcineurin-Crz1 signaling in lower eukaryotes

S Thewes - Eukaryotic cell, 2014 - Am Soc Microbiol
Calcium ions are ubiquitous intracellular messengers. An increase in the cytosolic Ca2+
concentration activates many proteins, including calmodulin and the Ca2+/calmodulin …

Combination of fluconazole with non-antifungal agents: a promising approach to cope with resistant Candida albicans infections and insight into new antifungal agent …

S Liu, Y Hou, X Chen, Y Gao, H Li, S Sun - International journal of …, 2014 - Elsevier
The past decades have witnessed a dramatic increase in invasive fungal infections,
especially candidiasis. Despite the development of more effective new antifungal agents …

Oropharyngeal candidosis in HIV-infected patients—an update

S Patil, B Majumdar, SC Sarode, GS Sarode… - Frontiers in …, 2018 - frontiersin.org
Oropharyngeal candidosis (OPC) is an opportunistic fungal infection that is commonly found
in HIV-infected patients, even in the twenty-first century. Candida albicans is the main …

Candida lusitaniae: Biology, Pathogenicity, Virulence Factors, Diagnosis, and Treatment

DF Mendoza-Reyes, M Gómez-Gaviria… - Infection and Drug …, 2022 - Taylor & Francis
The incidence of fungal infections is increasing at an alarming rate and has posed a great
challenge for science in recent years. The rise in these infections has been related to the …

Synergistic Effect of Fluconazole and Calcium Channel Blockers against Resistant Candida albicans

S Liu, L Yue, W Gu, X Li, L Zhang, S Sun - PloS one, 2016 - journals.plos.org
Candidiasis has increased significantly recently that threatens patients with low immunity.
However, the number of antifungal drugs on the market is limited in comparison to the …