Pancreatic cancer: pathogenesis, screening, diagnosis, and treatment

LD Wood, MI Canto, EM Jaffee, DM Simeone - Gastroenterology, 2022 - Elsevier
Pancreatic ductal adenocarcinoma (PDAC) is a clinically challenging cancer, due to both its
late stage at diagnosis and its resistance to chemotherapy. However, recent advances in our …

[HTML][HTML] Extracellular vesicle-cell adhesion molecules in tumours: biofunctions and clinical applications

W Lin, J Fang, S Wei, G He, J Liu, X Li, X Peng… - Cell Communication and …, 2023 - Springer
Cell adhesion molecule (CAM) is an umbrella term for several families of molecules,
including the cadherin family, integrin family, selectin family, immunoglobulin superfamily …

The multicenter cancer of pancreas screening study: impact on stage and survival

M Dbouk, BW Katona, RE Brand, A Chak… - Journal of clinical …, 2022 - ascopubs.org
PURPOSE To report pancreas surveillance outcomes of high-risk individuals within the
multicenter Cancer of Pancreas Screening-5 (CAPS5) study and to update outcomes of …

Risk reduction and screening of cancer in hereditary breast-ovarian cancer syndromes: ESMO Clinical Practice Guideline☆

C Sessa, J Balmaña, SL Bober… - Annals of …, 2023 - annalsofoncology.org
Hereditary breast and ovarian cancer syndrome (HBOC) is clinically defined by family
history criteria, and molecularly defined by identification of germline pathogenic variants …

Pancreatic cancer: changing epidemiology and new approaches to risk assessment, early detection, and prevention

EM Stoffel, RE Brand, M Goggins - Gastroenterology, 2023 - Elsevier
Pancreatic cancer usually results in poor survival with limited options for treatment, as most
affected individuals present with advanced disease. Early detection of preinvasive …

[HTML][HTML] Surveillance for pancreatic cancer in high-risk individuals leads to improved outcomes: a propensity score-matched analysis

DCF Klatte, B Boekestijn, AM Onnekink, FW Dekker… - Gastroenterology, 2023 - Elsevier
Background & Aims Recent pancreatic cancer surveillance programs of high-risk individuals
have reported improved outcomes. This study assessed to what extent outcomes of …

[HTML][HTML] Pancreatic cancer in chronic pancreatitis: pathogenesis and diagnostic approach

G Le Cosquer, C Maulat, B Bournet, P Cordelier… - Cancers, 2023 - mdpi.com
Simple Summary Chronic alcoholic pancreatitis displays a cumulative risk of pancreatic
cancer estimated at 4% after 15 to 20 years, this risk being higher for hereditary pancreatitis …

Liquid biopsy in pancreatic cancer–Current perspective and future outlook

Y Zhao, J Tang, K Jiang, SY Liu, A Aicher… - … et Biophysica Acta (BBA …, 2023 - Elsevier
Pancreatic cancer is a lethal condition with a rising incidence and often presents at an
advanced stage, contributing to abysmal five-year survival rates. Unspecific symptoms and …

Automated artificial intelligence model trained on a large data set can detect pancreas cancer on diagnostic computed tomography scans as well as visually occult …

P Korfiatis, G Suman, NG Patnam, KH Trivedi… - Gastroenterology, 2023 - Elsevier
Background & Aims The aims of our case-control study were (1) to develop an automated 3-
dimensional (3D) Convolutional Neural Network (CNN) for detection of pancreatic ductal …

Early diagnosis of pancreatic cancer: clinical premonitions, timely precursor detection and increased curative-intent surgery

K Søreide, W Ismail, M Roalsø, J Ghotbi… - Cancer …, 2023 - journals.sagepub.com
Background The overall poor prognosis in pancreatic cancer is related to late clinical
detection. Early diagnosis remains a considerable challenge in pancreatic cancer …