Targeting inflammation to treat diabetic kidney disease: the road to 2030

S Rayego-Mateos, RR Rodrigues-Diez… - Kidney international, 2023 - Elsevier
Diabetic kidney disease (DKD) is one of the fastest growing causes of chronic kidney
disease and associated morbidity and mortality. Preclinical research has demonstrated the …

[HTML][HTML] Mitochondrial dysfunction in diabetic tubulopathy

L Yao, X Liang, Y Qiao, B Chen, P Wang, Z Liu - Metabolism, 2022 - Elsevier
Diabetic kidney disease (DKD) is a devastating microvascular complication associated with
diabetes mellitus. Recently, the major focus of glomerular lesions of DKD has partly shifted …

GLP-1 and the kidney: from physiology to pharmacology and outcomes in diabetes

MHA Muskiet, L Tonneijck, MM Smits… - Nature Reviews …, 2017 - nature.com
The gastrointestinal tract—the largest endocrine network in human physiology—
orchestrates signals from the external environment to maintain neural and hormonal control …

Inflammatory targets in diabetic nephropathy

J Donate-Correa, D Luis-Rodríguez… - Journal of Clinical …, 2020 - mdpi.com
One of the most frequent complications in patients with diabetes mellitus is diabetic
nephropathy (DN). At present, it constitutes the first cause of end stage renal disease, and …

Diabetic kidney diseases revisited: A new perspective for a new era

H Fu, S Liu, SI Bastacky, X Wang, XJ Tian, D Zhou - Molecular metabolism, 2019 - Elsevier
Background Globally, diabetic kidney disease (DKD) is the leading cause of end-stage renal
disease. As the most common microvascular complication of diabetes, DKD is a thorny …

Emerging theranostic nanomaterials in diabetes and its complications

Y Liu, S Zeng, W Ji, H Yao, L Lin, H Cui… - Advanced …, 2022 - Wiley Online Library
Diabetes mellitus (DM) refers to a group of metabolic disorders that are characterized by
hyperglycemia. Oral subcutaneously administered antidiabetic drugs such as insulin …

Mesenchymal stem cell-derived exosomes ameliorated diabetic nephropathy by autophagy induction through the mTOR signaling pathway

N Ebrahim, IA Ahmed, NI Hussien, AA Dessouky… - Cells, 2018 - mdpi.com
Background: Diabetic nephropathy (DN) is a serious complication of diabetes mellitus and a
common cause of end-stage renal disease. Autophagy has a defensive role against kidney …

Targeting inflammation in diabetic nephropathy: a tale of hope

JA Moreno, C Gomez-Guerrero, S Mas… - Expert opinion on …, 2018 - Taylor & Francis
Introduction: Diabetic nephropathy (DN) is the leading cause of chronic kidney disease
(CKD) and end-stage renal disease (ESRD). Beyond the new anti-diabetic drugs that …

NLRP3 deficiency ameliorates renal inflammation and fibrosis in diabetic mice

M Wu, W Han, S Song, Y Du, C Liu, N Chen… - Molecular and cellular …, 2018 - Elsevier
Diabetic nephropathy (DN) is the leading cause of end-stage renal disease. Activation of the
nucleotide binding and oligomerization domain-like receptor family pyrin domain-containing …

Dissecting fibrosis: therapeutic insights from the small-molecule toolbox

CB Nanthakumar, RJD Hatley, S Lemma… - Nature reviews Drug …, 2015 - nature.com
Fibrosis, which leads to progressive loss of tissue function and eventual organ failure, has
been estimated to contribute to~ 45% of deaths in the developed world, and so new …