The role of paraoxonase in cancer
The paraoxonase (PON) gene family includes three proteins, PON1, PON2 and PON3.
PON1 and PON3 are both associated with high-density lipoprotein (HDL) particles and exert …
PON1 and PON3 are both associated with high-density lipoprotein (HDL) particles and exert …
[HTML][HTML] Modulatory effect of lifestyle-related, environmental and genetic factors on paraoxonase-1 activity: a review
D Kunachowicz, M Ściskalska, M Kepinska - International Journal of …, 2023 - mdpi.com
Paraoxonase-1 (PON1) is a calcium-dependent, HDL-bound serum hydrolase active toward
a wide variety of substrates. PON1 displays three types of activities, among which lactonase …
a wide variety of substrates. PON1 displays three types of activities, among which lactonase …
The antidiabetic and anticholinergic effects of chrysin on cyclophosphamide‐induced multiple organ toxicity in rats: Pharmacological evaluation of some metabolic …
Abstract Chrysin (CH) or 5, 7‐dihydroxyflavone is a flavonoid present in various plants, bee
propolis, and honey. Cyclophosphamide (CYP) is a chemotherapeutic drug, which is …
propolis, and honey. Cyclophosphamide (CYP) is a chemotherapeutic drug, which is …
The effects of hesperidin on sodium arsenite‐induced different organ toxicity in rats on metabolic enzymes as antidiabetic and anticholinergics potentials: A …
In our work, it was purposed to investigate the effects of sodium arsenite (SA) and hesperidin
(HSP) administered to rats on some metabolic enzymes including carbonic anhydrase (CA) …
(HSP) administered to rats on some metabolic enzymes including carbonic anhydrase (CA) …
The behaviour of some antihypertension drugs on human serum paraoxonase-1: an important protector enzyme against atherosclerosis
Y Demir - Journal of pharmacy and pharmacology, 2019 - academic.oup.com
Abstract Objectives Paraoxonase-1 (PON1) enzyme is related to high-density lipoprotein
(HDL), which is calcium dependent. It has essential roles such as protecting LDL against …
(HDL), which is calcium dependent. It has essential roles such as protecting LDL against …
Biological evaluation and in silico study of benzohydrazide derivatives as paraoxonase 1 inhibitors
IN Korkmaz, C Türkeş, Y Demir… - … of Biochemical and …, 2022 - Wiley Online Library
Abstract Serum paraoxonase 1 (PON1) is found in all mammalian species and is a calcium‐
dependent hydrolytic enzyme. PON1 hydrolyze several substrates, including carbonates …
dependent hydrolytic enzyme. PON1 hydrolyze several substrates, including carbonates …
A potential risk factor for paraoxonase 1: in silico and in-vitro analysis of the biological activity of proton-pump inhibitors
C Türkeş - Journal of Pharmacy and Pharmacology, 2019 - academic.oup.com
Abstract Objectives Proton-pump inhibitors (PPIs) are drugs commonly utilized by about 7%
of adults in the world. Recent researches have shown that there are countless and severe …
of adults in the world. Recent researches have shown that there are countless and severe …
Benzenesulfonamide derivatives containing imine and amine groups: Inhibition on human paraoxonase and molecular docking studies
Sulfonamides known as inhibitors of many metabolic enzymes have been widely used as
antimicrobial drugs for a long time. In the present study, we investigated in vitro inhibitory …
antimicrobial drugs for a long time. In the present study, we investigated in vitro inhibitory …
Molecular docking studies and inhibition properties of some antineoplastic agents against paraoxonase-I
Y Demir, C Türkeş, Ş Beydemir - Anti-Cancer Agents in …, 2020 - ingentaconnect.com
Background: Currently, most of the drugs used in clinical applications show their
pharmacological influences by inhibiting or activating enzymes. Therefore, enzyme …
pharmacological influences by inhibiting or activating enzymes. Therefore, enzyme …
Investigation of potential paraoxonase-I inhibitors by kinetic and molecular docking studies: chemotherapeutic drugs
C Türkeş - Protein and peptide letters, 2019 - ingentaconnect.com
Background: Metabolic processes in living organisms are closely related to the catalytic
activity of enzymes. Changes in enzyme activity cause various diseases eg, neurological …
activity of enzymes. Changes in enzyme activity cause various diseases eg, neurological …